6,7-Dimethoxyisoquinoline TCI D4089

Name: TCI D4089 15248-39-2 6,7-Dimethoxyisoquinoline
Brand: TCI
SKU: TCI2510D408924574
Price: 5577600.0 IDR
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Berat 1g

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Description

TCI D4089, CAS 15248-39-2, is 6,7-Dimethoxyisoquinoline, a nitrogen-containing heterocyclic compound classified within the heterocyclic building blocks group. The molecule is built on an isoquinoline framework — a benzene ring fused to a pyridine ring — carrying two methoxy substituents at the 6 and 7 positions. This 6,7-dimethoxy substitution pattern on an isoquinoline core is a widely recognised motif in natural product chemistry, appearing repeatedly across the benzylisoquinoline class of alkaloids. As a result, the compound serves as a highly useful starting point for researchers constructing alkaloid analogues and drug candidates.

The properties that make this material a preferred choice come from the combination of a basic nitrogen atom in the pyridine ring and two electron-donating methoxy groups. The isoquinoline nitrogen can act as a nucleophile, as a base, or as a quaternisation site, and it allows the formation of salts that are useful for purification or for adjusting solubility. The methoxy groups increase electron density on the aromatic ring, thereby directing electrophilic substitution reactions and influencing the spectroscopic profile of the compound. The isoquinoline framework can also be reduced in a controlled manner toward dihydro or tetrahydro forms.

In Indonesian laboratories, this building block is typically used in university and institutional synthetic chemistry groups, natural product research programmes, and medicinal chemistry laboratories working on alkaloid-inspired structures. It is handled in ordinary bench-scale organic synthesis workflows, where researchers assemble intermediates, run derivatisation steps, and verify structures by routine spectroscopic methods. Its role is that of a defined heterocyclic starting material rather than a finished reagent formulation.

Laboratory Applications

Benzylisoquinoline alkaloid analogue synthesis: the 6,7-dimethoxyisoquinoline motif recurs throughout this alkaloid class, so the compound provides a ready-made core that shortens routes toward natural-product-like targets.
Medicinal chemistry scaffold development: the basic pyridine-type nitrogen and the two electron-donating methoxy groups give chemists several handles for building and tuning drug candidate analogues.
Controlled reduction studies: the isoquinoline framework can be reduced in a controlled fashion toward dihydro or tetrahydro forms, making the material suitable for work on partially saturated heterocyclic intermediates.
Quaternisation and salt formation work: the isoquinoline nitrogen functions as a quaternisation site and forms salts, which researchers exploit to purify intermediates or to adjust the solubility of a compound.
Electrophilic aromatic substitution investigations: the methoxy substituents raise aromatic electron density and direct incoming electrophiles, so the compound suits regiochemistry studies on a substituted heterocyclic ring.

Specifications

Brand: TCI
CAS number: 15248-39-2
Chemical name: 6,7-Dimethoxyisoquinoline
Product code: D4089
Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
Pack sizes: available in the standard research-scale packaging offered by the manufacturer; storage should follow the conditions stated on the manufacturer's label and safety data sheet

Handling and Storage

Store this material in its original tightly closed container, kept in a cool, dry and well-ventilated area away from direct sunlight, heat sources and incompatible chemicals. Glass containers with chemically resistant closures are generally suitable, and the container should be reclosed promptly after each use to limit exposure to moisture and air. Follow the storage temperature and conditions stated on the manufacturer's label and safety data sheet, as these take precedence over general guidance. Handle the compound in a fume hood using appropriate personal protective equipment, including safety glasses, chemically resistant gloves and a laboratory coat. Avoid generating dust, avoid contact with skin and eyes, and wash hands thoroughly after handling. Keep the label legible, record the opening date, and dispose of residues and contaminated materials through the laboratory's chemical waste procedures in accordance with applicable regulations.