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Description
TCI D4813 2,4-Dimethylthiazole-5-carboxylic Acid is a heterocyclic building block based on the thiazole ring, a five-membered ring containing both a nitrogen and a sulfur atom. The compound carries two methyl groups at positions 2 and 4, together with a carboxylic acid group at position 5. In the laboratory, it serves as an acid-functionalized building block that is ready to be joined to amines, alcohols, or other nucleophiles through amide and ester formation reactions. The thiazole core itself is a motif that appears very frequently in pharmaceutical active ingredients as well as in agrochemical materials.
The properties that make this compound a preferred choice are its practicality and reliability as a coupling partner. The carboxylic acid group can be activated directly with common coupling reagents such as EDC, DCC, or HATU, or converted into the corresponding acid chloride, so that amide formation proceeds smoothly under conditions that are already well established. The thiazole ring is aromatic and reasonably resistant to ordinary reaction conditions, yet it still makes an important contribution to the properties of the final molecule: the sulfur and nitrogen atoms provide hydrogen-bond acceptor sites and weak interactions that often improve affinity toward biological targets. The two methyl groups add further character to the substitution pattern around the ring.
In Indonesian laboratories, this building block is typically used in synthetic organic chemistry groups at universities and research institutes, as well as in the exploratory work of pharmaceutical and agrochemical developers. It is generally ordered in small research quantities for the preparation of amide and ester derivative series, for structure–activity exploration around a thiazole core, and for teaching or method-development work in graduate research programs where a dependable, well-characterized heterocyclic acid is required as a starting point.
Laboratory Applications
- Amide coupling reactions, where the free carboxylic acid at position 5 can be activated with EDC, DCC, or HATU and joined to a wide range of amine partners under standard, well-documented conditions.
- Ester synthesis, in which the acid group reacts with alcohols to give thiazole-containing esters, providing a convenient route to intermediates and protected forms for further synthetic elaboration.
- Acid chloride chemistry, since the carboxylic acid can be converted into the corresponding acid chloride for more reactive acylation steps when a direct coupling reagent approach is not suitable.
- Pharmaceutical discovery chemistry, because the thiazole core is a motif that appears very frequently in active pharmaceutical ingredients and contributes hydrogen-bond acceptor sites through its nitrogen and sulfur atoms.
- Agrochemical research synthesis, where the same thiazole framework is a common structural element and the dimethyl substitution pattern offers a defined starting point for building candidate structures.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- CAS Number: 53137-27-2
- Catalogue Code: D4813
- Chemical Name: 2,4-Dimethylthiazole-5-carboxylic Acid
- Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
- Pack Sizes: available in standard research-scale pack sizes; please refer to the current catalogue listing for the options offered
- Storage: keep in the tightly closed original container, in a cool, dry, well-ventilated place
Handling and Storage
Store the material in its original tightly closed container in a cool, dry, and well-ventilated area, away from direct sunlight, moisture, and sources of heat or ignition. Glass or chemically compatible plastic containers with secure caps are suitable for transfer and short-term storage of working portions, and all containers should remain clearly labelled. Handle the solid in a fume hood or a well-ventilated workspace to avoid the generation and inhalation of dust, and wear standard laboratory personal protective equipment, including a lab coat, safety glasses, and chemically resistant gloves. Keep the compound separated from strong oxidizing agents and strong bases, and avoid contact with skin and eyes. Use clean, dry spatulas when weighing to prevent contamination of the bulk material, and close the container promptly after use. Always consult the manufacturer's Safety Data Sheet before handling and follow your institution's chemical waste disposal procedures.
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