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Description
TCI E0718 2-Ethyl-4,5-dimethylthiazole (CAS 873-64-3) is a nitrogen- and sulfur-containing heterocyclic compound of the thiazole class, supplied by Tokyo Chemical Industry as a building block for organic synthesis. The thiazole ring carries an ethyl group at position 2 and two methyl groups at positions 4 and 5, giving researchers a ready-made scaffold for constructing more complex heterocyclic structures without having to assemble the ring themselves. In the laboratory, this material commonly serves as a starting reagent in reaction sequences, as a comparison standard in analytical work on aroma compounds, and as a reference material in flavour and odour chemistry studies that require a well-characterised thiazole.
The properties that make this compound a preferred choice lie in the thiazole ring itself. The ring nitrogen atom is both weakly basic and nucleophilic, so it can be directed toward alkylation reactions or toward coordination with metals, while the sulfur atom contributes the ring's characteristic aromatic character and thermal stability sufficient for reactions heated at moderate temperatures. The alkyl substituents at three positions on the ring provide controlled steric and electronic effects, so reaction patterns remain predictable and the scaffold behaves consistently across repeated preparations rather than requiring fresh optimisation each time.
In Indonesian laboratories, this compound is typically used in university and institutional research groups working on heterocyclic synthesis, and in analytical laboratories dealing with flavour and fragrance characterisation. Because the substituted thiazole ring is already built, work can begin at the derivatisation stage, which suits teaching laboratories and research units that need dependable intermediates on hand. Its role as a characterised reference compound also makes it useful where instrumental methods must be checked against a known thiazole.
Laboratory Applications
- Heterocyclic synthesis starting material — the pre-formed thiazole ring lets chemists move directly to derivatisation steps instead of spending effort constructing the five-membered ring from precursors.
- Alkylation chemistry at the ring nitrogen — the weakly basic, nucleophilic nitrogen atom offers a defined reactive site for building quaternised thiazolium derivatives and related nitrogen-functionalised products.
- Metal coordination studies — the ring nitrogen can act as a donor atom toward metal centres, making the compound useful for preparing and examining thiazole-based coordination complexes.
- Aroma compound analysis — the material functions as a comparison substance during analytical work on aroma-active compounds, supporting identification against a known, characterised thiazole structure.
- Flavour and odour chemistry research — studies in taste and smell chemistry rely on well-characterised thiazoles as reference materials, and this substituted thiazole fills that role in such investigations.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- CAS number: 873-64-3
- Product code: E0718
- Chemical name: 2-Ethyl-4,5-dimethylthiazole
- Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
- Pack sizes: available in the standard TCI catalogue pack sizes; please confirm the required size when ordering
- Storage: store in a tightly closed container in a cool, dry, well-ventilated place
Handling and Storage
Store this compound in a cool, dry and well-ventilated place, away from direct sunlight, heat sources and ignition sources. Keep it in a tightly closed original container, or in a chemically compatible glass bottle with a secure cap, and keep the container sealed when not in use so that the material is not exposed to air and moisture longer than necessary. Because thiazoles carry a strong characteristic odour, handle and transfer the compound inside a fume hood. Wear safety goggles, gloves and a laboratory coat, avoid contact with skin and eyes, and avoid breathing vapour. Label containers clearly, store away from strong oxidising agents, and consult the manufacturer's safety data sheet before use and before disposal of residues.
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