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CAS 3581-91-7

4,5-Dimethylthiazole TCI D2142

4,5-Dimethylthiazole TCI D2142
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TCI D2142, with CAS number 3581-91-7, is 4,5-Dimethylthiazole — a five-membered heterocyclic compound containing one nitrogen atom and one sulfur atom within its ring, carrying two methyl groups at positions 4 and 5. In the laboratory, this material is classified as a heterocyclic building block, meaning it serves as a ready-made scaffold that already contains the thiazole core, so researchers do not need to construct that ring from scratch. The thiazole core itself is a motif encountered very frequently in bioactive compounds, coordination ligands, and aroma compounds, which makes this material a versatile reagent for synthetic work.

The properties that make this compound a preferred choice are the combination of the aromaticity of the thiazole ring with the lone pair on the nitrogen atom, which is weakly basic and capable of coordinating to metals. Position 2 of the ring remains open, so a clear reactive site is available for deprotonation, lithiation, or further substitution. The two methyl groups at positions 4 and 5 increase the electron density of the ring while simultaneously directing reactions toward the remaining position. Its physical form is a liquid at room temperature with a characteristically sharp odour, so handling and dispensing are normally carried out with appropriate technique and equipment.

In Indonesian laboratories, this material is typically used in synthetic organic chemistry groups at universities and research institutes, as well as in industrial development work where the thiazole core is required as a starting scaffold. Because it arrives as a liquid with a pronounced odour, it is generally dispensed inside a fume hood and returned promptly to storage. Its role as a building block means it is usually ordered in modest quantities for method development and small-scale synthesis rather than for bulk processing.

  • Heterocyclic synthesis — the intact thiazole ring lets researchers begin from a finished core instead of constructing the nitrogen–sulfur heterocycle themselves, shortening synthetic routes considerably.
  • Functionalisation at position 2 — the open position 2 provides a clearly defined reactive site for deprotonation, lithiation, or substitution, giving predictable access to substituted thiazole derivatives.
  • Bioactive compound development — because the thiazole motif appears very frequently in bioactive compounds, this reagent serves as a convenient scaffold for preparing and screening candidate structures.
  • Coordination chemistry and ligand studies — the weakly basic lone pair on the ring nitrogen is able to coordinate with metals, making the compound useful for preparing and studying metal complexes.
  • Aroma compound research — the thiazole core is a recognised motif among aroma compounds, so this material supports laboratory work on flavour and fragrance chemistry and related derivatives.

Brand TCI
CAS number 3581-91-7
Molecular formula
Purity
Category Chemistry > Building Blocks > Heterocyclic Building Blocks
Pack sizes available in the standard catalogue pack sizes offered for this item
Physical form liquid at room temperature, with a characteristically sharp odour
Storage keep tightly closed in its original container, away from heat and direct sunlight
  • Chemical name: 4,5-Dimethylthiazole

Store this material in a tightly closed original container, kept cool, dry, and away from heat sources and direct sunlight. Because the product is a liquid at room temperature with a sharp characteristic odour, all transfers and dispensing should be performed inside a working fume hood, and the container should be resealed and returned to its designated storage location immediately after use. Use compatible glassware and closures for transfers, and avoid leaving open containers on the bench. Standard laboratory personal protective equipment — gloves, safety glasses, and a laboratory coat — should be worn throughout handling. Consult the supplied safety data sheet for detailed handling, exposure, and disposal guidance before beginning work.