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Description
TCI F0635 5-Fluoro-1-(tetrahydro-2-furfuryl)uracil is a fluorinated uracil derivative in which the pyrimidine ring is bonded to a tetrahydrofurfuryl group. The compound is widely recognised in the research literature as a classic example of the prodrug approach — the strategy of modifying an active compound so that its absorption and distribution properties are altered before the compound is released again in its active form inside the body. For this reason the material is classified within the drug delivery system research reagent group, and in the laboratory it is used as a reference material and as a test substance in pharmaceutical research, not for direct clinical use.
The property that makes this material a preferred choice is the combination of the 5-fluorouracil core with the tetrahydrofurfuryl group that caps the nitrogen position. This modification changes the solubility and the chemical profile of the molecule compared with its parent compound, making it a highly useful model for studying how structural changes influence the release of an active compound. The fluorine atom at the fifth position of the uracil ring is the characteristic feature of the widely studied pyrimidine antimetabolites, and its presence also makes the compound convenient to monitor by fluorine-19 NMR spectroscopy.
For researchers working in Indonesian laboratories, a TCI-branded reagent of this kind is normally ordered for pharmaceutical development and drug discovery work in university research groups, pharmacy faculties, and formulation development laboratories. It typically serves as a reference or comparison substance in method development and in prodrug-related studies, where a well-characterised, literature-supported compound is needed so that results can be compared against published work rather than against an uncharacterised in-house material.
Laboratory Applications
Prodrug concept studies — the compound is a classic literature example of a modified active substance, so it serves as a dependable teaching and research model for how prodrug strategies alter absorption and distribution behaviour.
Drug delivery system research — because its tetrahydrofurfuryl group caps the nitrogen position of the uracil ring, it directly illustrates how a delivery-oriented structural modification changes a molecule before the active form is released.
Structure–release relationship investigations — the altered solubility and chemical profile relative to the parent compound make it a useful model for examining how specific structural changes influence the release of the active compound.
Fluorine-19 NMR spectroscopy work — the fluorine atom at the fifth position of the uracil ring provides a clear spectroscopic handle, allowing the compound to be monitored and tracked conveniently in NMR-based studies.
Pyrimidine antimetabolite research — as a fluorinated uracil derivative, it belongs to a compound class that has been extensively studied, making it suitable as a reference or comparison substance in pharmaceutical research programmes.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS number: 17902-23-7
Chemical name: 5-Fluoro-1-(tetrahydro-2-furfuryl)uracil
Category: Chemistry > Pharmaceutical Development and Drug Discovery Research Reagents > Drug Delivery Systems (DDS)
Pack sizes: available in the standard research-scale pack sizes offered by the manufacturer; please confirm the currently available packaging when ordering
Storage: store according to the conditions stated on the manufacturer's label and product documentation
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated place, away from direct sunlight, heat sources, and moisture, following the storage conditions printed on the manufacturer's label. Keep the material in its original supplier container, or transfer it only to a clean, chemically compatible and clearly labelled container that is reserved for this substance. Handle the compound as a pharmaceutical research reagent intended for laboratory use only and not for direct clinical application. Work in a fume hood, wear a laboratory coat, safety goggles, and suitable chemical-resistant gloves, and avoid generating or inhaling dust when weighing the solid. Use clean, dry spatulas to prevent contamination, close the container promptly after use, and consult the manufacturer's safety data sheet before handling or disposal.
