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Description
TCI F0656 2-Fluoroadenosine is a purine nucleoside analogue — an adenosine derivative carrying a fluorine atom at the second position of the purine ring. A nucleoside itself is one of the building blocks of nucleic acids, consisting of a nitrogenous base joined to a ribose sugar. In the laboratory, this compound serves both as a biochemical research material and as an important intermediate in nucleoside chemistry, including as a core scaffold for preparing other purine analogues. Having it available in purified form saves researchers the considerable time they would otherwise spend preparing it themselves through a long sequence of multi-step synthesis.
The characteristic that makes this compound a preferred choice is the influence of the fluorine atom on the purine ring. Fluorine substitution alters the electronic properties of the purine base and increases its resistance to a number of enzymatic deamination pathways that would normally convert adenosine rapidly, so the analogue is considerably more durable in biological experimental systems. The ribose framework remains intact, which means the compound is still recognised by various enzymes and nucleoside-binding proteins, making it well suited as a tool for tracing purine metabolic pathways. It is this combination of structural similarity to the natural substrate and improved stability that gives the material its value.
In Indonesian laboratories, 2-Fluoroadenosine is typically encountered in university and institutional research settings working on biochemistry, molecular biology, and synthetic nucleoside chemistry. It is usually ordered in small research quantities for work carried out at the bench rather than at production scale, and is handled alongside other fine biochemical reagents in facilities equipped for controlled storage. Its role is generally that of a specialised reference or starting material within a defined experimental programme.
Laboratory Applications
Purine metabolism studies: the intact ribose framework keeps the molecule recognisable to nucleoside-binding proteins and enzymes, allowing researchers to follow purine pathways using a probe that closely resembles the natural substrate.
Nucleoside analogue synthesis: the compound serves as a core purine scaffold from which other analogues can be built, removing the need for laboratories to carry out a long multi-step preparation of the starting material themselves.
Enzymatic deamination research: because fluorine substitution raises resistance to several deamination pathways that rapidly convert adenosine, the analogue is useful for investigating how such enzymatic conversions proceed and where they can be blocked.
Biochemical assay work: the increased durability of this analogue in biological systems means it persists longer under experimental conditions than adenosine itself, giving more workable time windows in bench assays.
Structure–activity investigations: the single fluorine substitution on the purine ring alters electronic properties while leaving the overall nucleoside structure intact, making it a useful comparison point against unmodified adenosine.
Specifications
Brand: TCI
CAS number: 146-78-1
Category: Life Science > Biochemicals and Reagents > Nucleosides, Nucleotides, Oligonucleotides
Chemical class: purine nucleoside analogue; adenosine derivative fluorinated at the 2-position of the purine ring
Pack sizes: supplied in research-scale quantities; please confirm the available pack size when ordering
Storage: store according to the conditions stated on the manufacturer's label and accompanying documentation
Handling and Storage
Store the container in a cool, dry place away from direct sunlight, moisture, and heat sources, following the storage conditions printed on the manufacturer's label. Keep the material in its original tightly closed container, or in a comparable chemically compatible, well-sealed vessel, and label it clearly. Allow refrigerated or frozen stock to reach room temperature before opening so that condensation does not enter the container. Handle the compound in a well-ventilated area or fume hood using standard personal protective equipment — laboratory coat, safety glasses, and suitable gloves. Avoid generating dust, avoid contact with skin and eyes, and consult the manufacturer's Safety Data Sheet before use and before any disposal step.
