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Description
TCI F0661 2-Fluoro-3-nitrotoluene is a fluorinated aromatic compound that carries a methyl group, a fluorine atom, and a nitro group on a single benzene ring. It belongs to the building block category, meaning it serves as a starting material used to assemble more complex molecules through a sequence of stepwise reactions. In the laboratory, its role is to supply a neatly substituted aromatic framework with predetermined substituent positions, so that researchers do not have to carry out their own nitration or fluorination steps, which risk producing isomer mixtures and adding to the purification workload.
The characteristic that makes this compound a preferred choice is the presence of its highly versatile nitro group. The nitro group can be reduced to an aromatic amine, a key functional group that serves as the gateway to amides, ureas, sulfonamides, and a wide range of heterocyclic rings. The nitro group is also strongly electron-withdrawing, which activates the adjacent fluorine atom toward nucleophilic aromatic substitution and opens a second reaction pathway that may be carried out first. The methyl group itself can be oxidized to a carboxylic acid or elaborated further. Together, these three groups give researchers three clearly defined points of modification on one small molecule.
In Indonesian laboratories, this material is typically encountered in synthetic organic chemistry work where a defined aromatic scaffold is needed as the entry point to a longer preparation route. It suits university research groups, postgraduate synthesis projects, and research and development units that build target molecules step by step and prefer to begin from a substituted ring with fixed positions rather than generating that substitution pattern in-house, which saves both reaction time and purification effort.
Laboratory Applications
- Nitro group reduction to aromatic amine: the nitro substituent converts cleanly to an aniline derivative, providing the key intermediate from which amides, ureas, sulfonamides, and heterocyclic systems are subsequently constructed.
- Nucleophilic aromatic substitution on the fluorine position: the strongly electron-withdrawing nitro group activates the neighbouring fluorine, allowing nucleophiles to displace it and install new substituents directly on the ring.
- Multistep synthesis of complex target molecules: three distinct handles on one small aromatic core let researchers plan sequential transformations without needing separate starting materials for each modification.
- Oxidation chemistry at the methyl group: the methyl substituent can be oxidized to a carboxylic acid or otherwise elaborated, extending the range of derivatives obtainable from a single compound.
- Preparation of fluorinated intermediates and scaffolds: using a ready-made fluorinated ring avoids in-house fluorination and nitration, removing the isomer mixtures and heavy purification burden those reactions typically create.
Specifications
- Brand: TCI
- CAS number: 437-86-5
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Chemical name: 2-Fluoro-3-nitrotoluene
- Pack sizes: available in standard TCI catalogue pack sizes; please confirm the required quantity when ordering
- Storage: store according to the conditions stated on the manufacturer label and the accompanying safety data sheet
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated area away from direct sunlight, heat sources, and incompatible materials, following the conditions stated on the manufacturer label and the safety data sheet. Keep the material in its original supplier packaging or in a chemically compatible, clearly labelled container, and reseal it promptly after each use to limit exposure to air and moisture. Handle the compound inside a functioning fume hood and wear appropriate personal protective equipment, including safety goggles, chemical-resistant gloves, and a laboratory coat. As with other nitroaromatic materials, avoid inhalation, skin contact, and eye contact, keep the work area clean, and dispose of residues and contaminated materials through the laboratory's established chemical waste procedures.
