• 6299-87-2 6-Hydroxy-4-pyrimidinecarboxylic Acid - AMI Scientific
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TCI

CAS 6299-87-2

6-Hydroxy-4-pyrimidinecarboxylic Acid TCI H1392

6-Hydroxy-4-pyrimidinecarboxylic Acid TCI H1392
Rp 562.800,00
Rp 562.800,00
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TCI H1392 6-Hydroxy-4-pyrimidinecarboxylic Acid is a nitrogen-containing heterocyclic compound that combines a pyrimidine ring with a hydroxyl group and a carboxylic acid group at defined ring positions. In synthetic laboratories, this compound serves as a heterocyclic building block that supplies a ready-made pyrimidine core, allowing researchers to move directly into the functionalization stage instead of constructing the ring from scratch through lengthy condensation reactions that frequently deliver low yields. Supplied by TCI under catalogue number H1392, it belongs to the heterocyclic building blocks family within the broader chemistry portfolio.

The properties that make this compound a preferred choice begin with the carboxylic acid group, which is readily activated and converted into amides or esters through standard coupling chemistry. This is paired with the hydroxyl group on the ring, which can be transformed into a leaving group by chlorination and thereby opens the way to nucleophilic aromatic substitution. These two distinct reaction pathways give considerable flexibility in designing a synthetic sequence. The pyrimidine ring itself is a highly valued core in medicinal chemistry because it forms the basic framework of the nucleic acid bases, so its derivatives frequently display interesting biological interactions.

In Indonesian laboratories, this compound is generally encountered as a solid with good stability under appropriate storage conditions, which makes it practical for research groups that order materials in discrete batches and draw on them over an extended period. It is typically used in university synthetic chemistry laboratories, pharmaceutical research groups, and institutional research centres where heterocyclic scaffolds are elaborated into more complex target molecules, and where a stable, ready-to-use pyrimidine core shortens the route to the compounds actually under study.

  • Heterocyclic scaffold synthesis — the ready-made pyrimidine core removes the need to build the ring through long condensation sequences that often give low and variable yields.
  • Amide and ester derivative preparation — the carboxylic acid group is easily activated, letting researchers append amines or alcohols to generate focused libraries of related pyrimidine derivatives.
  • Nucleophilic aromatic substitution chemistry — chlorination converts the ring hydroxyl into a leaving group, enabling nucleophiles to be installed directly onto the pyrimidine ring.
  • Medicinal chemistry research — the pyrimidine framework underlies the nucleic acid bases, so derivatives built from this material frequently show interesting biological interactions worth investigating.
  • Multi-step route design — two independent reactive handles on one small molecule give chemists real flexibility in ordering transformations across a planned synthetic sequence.

Brand TCI (Tokyo Chemical Industry), catalogue number H1392
CAS number 6299-87-2
Molecular formula —
Purity —
Category Chemistry > Building Blocks > Heterocyclic Building Blocks
Pack sizes available in standard TCI research-scale packaging; please confirm the size required when ordering
Physical form solid
Storage store under the conditions stated on the manufacturer label to maintain its good stability

Store this compound in its original tightly closed container, kept in a cool, dry, and well ventilated area away from moisture and direct sunlight, following the conditions stated on the manufacturer label. Glass containers with chemically resistant closures are suitable for any repackaging, and containers should be clearly labelled with the compound name and CAS number. Handle the solid in a fume hood to avoid generating or inhaling dust, and wear appropriate personal protective equipment including safety goggles, chemical resistant gloves, and a laboratory coat. Close the container immediately after use, avoid contact with skin and eyes, and consult the manufacturer safety data sheet before first use. Dispose of residues and contaminated materials according to institutional chemical waste procedures.

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