3-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-5-amine TCI O0699

Chemical Identity

CAS No.: 2251054-52-9
Purity: >95.0%(qNMR)

Rp 5.062.050,00

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Berat 100mg

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3-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-5-amine from TCI is a heterocyclic building block. It combines a pyrazolo[3,4-b]pyridine scaffold with a tetrahydropyran-4-yl substituent and a primary amine group at the 5-position. In the laboratory it serves as an intermediate for assembling more complex molecules, especially in medicinal chemistry and drug discovery. Researchers often use nitrogen-rich bicyclic frameworks like this one as core structures when they design compound libraries for biological activity screening.

Chemists choose this compound because it brings several useful structural features together in one molecule. The aromatic amine gives a clear reactive handle for amidation, urea formation, sulfonamide synthesis or C–N coupling reactions, so researchers can add a range of substituents in a controlled way. Molecular designers often use the tetrahydropyran ring to adjust polarity and solubility without adding overly reactive groups. The pyrazolopyridine core also has a pattern of hydrogen-bond donors and acceptors that is of interest in studies of how molecules interact with target proteins.

In Indonesia, materials like this are relevant to university research groups in organic and medicinal chemistry, pharmaceutical research and development laboratories, and institutions working on early-stage drug discovery. The compound is typically used at small research scale in synthesis laboratories, where it is a starting point for building analogue series, exploring structure–activity relationships, or preparing reference compounds for academic and industrial projects that need well-defined heterocyclic intermediates.

TCI brochures (PDF)

Building Blocks for Medicinal Chemistry 2025-05-12 · p. 2

Related TCI products

Medicinal chemistry synthesis: the pyrazolo[3,4-b]pyridine core with a primary amine is a versatile scaffold for building drug-like candidate molecules by targeted functionalisation.
Amide and urea library preparation: the aromatic amine at the 5-position reacts readily with acylating agents and isocyanates, so researchers can generate diverse derivative series efficiently.
C–N cross-coupling studies: the amine group can take part in coupling reactions, letting chemists join this heterocycle to aryl or heteroaryl partners when building more elaborate frameworks.
Structure–activity relationship exploration: the tetrahydropyran substituent and the bicyclic core give a defined structure that researchers can modify step by step to see how changes affect biological activity.
Screening compound library design: the nitrogen-rich bicyclic framework, with its hydrogen-bond donor and acceptor pattern, suits libraries intended for studying molecular interactions with protein targets.

Brand	TCI (product code O0699)
CAS number	2251054-52-9
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Heterocyclic Building Blocks
Pack sizes	as offered by TCI for this product code; please confirm the available options when ordering
Physical form	refer to the TCI product documentation and certificate of analysis
Storage	follow the storage conditions on the TCI label and safety data sheet

Keep this compound in its original, tightly closed container, labelled clearly, in a cool, dry and well-ventilated area away from direct sunlight, moisture and incompatible substances such as strong oxidising agents. Always follow the specific storage temperature and conditions on the TCI label and safety data sheet. Handle the material in a fume hood or well-ventilated workspace, and wear suitable personal protective equipment, including a lab coat, safety glasses and chemical-resistant gloves. Avoid creating dust, avoid inhaling it or getting it on skin or in eyes, and wash your hands thoroughly after handling. Dispose of residues and contaminated materials according to local regulations and your institution's chemical waste procedures.

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