1-Propanesulfonyl Chloride from TCI, product code P0693 (CAS 10147-36-1), is an aliphatic sulfonyl chloride. Its molecule is a propyl chain attached to a sulfonyl chloride group. Organic synthesis laboratories use it as a sulfonylating reagent to add the propylsulfonyl group to other molecules. It reacts with amines to form sulfonamides and with alcohols to form sulfonate esters. Both product classes matter in medicinal chemistry, agrochemical chemistry, and materials development, so synthetic chemists treat this compound as a basic reagent.
Chemists choose this compound because the sulfur atom in the sulfonyl chloride group is strongly electrophilic. Nucleophiles attack it easily, and chloride leaves as the leaving group. Reactions usually run under mild conditions with a base such as triethylamine or pyridine. The short propyl chain gives moderate lipophilicity without much extra steric hindrance. This helps when researchers want to adjust the solubility or pharmacokinetic properties of a molecule. The sulfonamide group that forms is also chemically stable, so it holds up through later synthetic steps and purification.
In Indonesian laboratories, this reagent is mostly used in university organic chemistry research groups, pharmaceutical research and development units, and agrochemical development laboratories. Researchers use it to prepare sulfonamide derivatives for structure-activity studies, to make sulfonate esters as synthetic intermediates, and to modify building blocks during multi-step synthesis. Its role as a non-heterocyclic building block also makes it useful for teaching and for thesis-level synthesis projects. In those settings, students learn standard sulfonylation methods using common bases and solvents.
- Sulfonamide synthesis: the reagent reacts with primary and secondary amines under mild basic conditions and gives stable propylsulfonamides that medicinal chemistry programs commonly use.
- Sulfonate ester preparation: it reacts with alcohols in the presence of a base such as pyridine or triethylamine to give sulfonate esters, which serve as useful intermediates in multi-step synthesis.
- Medicinal chemistry structure-activity studies: the short propyl chain adds moderate lipophilicity with little steric bulk, which helps researchers tune solubility and pharmacokinetic behaviour across a series of analogues.
- Agrochemical research and development: sulfonamide and sulfonate motifs are important in agrochemical chemistry, so this reagent fits screening and derivatization work on candidate active compounds.
- Materials development and functionalization: the electrophilic sulfonyl chloride group lets researchers attach propylsulfonyl groups to nucleophilic sites on molecules or materials whose properties they want to modify.
| Brand | TCI (product code P0693) |
|---|---|
| CAS number | 10147-36-1 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Non-Heterocyclic Building Blocks |
| Pack sizes | as listed for this product by TCI; check the product page for the sizes available |
| Physical form | generally a liquid at room temperature |
| Storage | moisture-sensitive; keep the container tightly closed and protected from humidity |
1-Propanesulfonyl Chloride is sensitive to moisture, so keep it in its original tightly closed container in a cool, dry, well-ventilated area, away from water, alcohols, amines, and bases. Reseal the container promptly after each use. Many laboratories also keep moisture-sensitive reagents under an inert atmosphere. As with other sulfonyl chlorides, handle it in a fume hood and wear chemical-resistant gloves, safety goggles, and a lab coat. Avoid contact with skin, eyes, and vapours. Always follow the storage conditions and hazard information on the TCI label and Safety Data Sheet.
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