TCI C0283 6-Chloroquinoline (CAS 612-57-7) carries its chlorine substituent on the carbocyclic ring of the quinoline system. Because this position is not activated by the ring nitrogen, the compound is most often elaborated through palladium-catalysed cross-coupling rather than direct nucleophilic substitution. The retained ring nitrogen makes it useful as a precursor to ligands and metal complexes, while the rigid aromatic core suits medicinal chemistry and functional materials research. AMI Scientific supplies this TCI building block in convenient 1 g and 5 g research-scale packs.
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- da Silva et al. (2006). Standard molar enthalpies of formation of 2-chloroquinoline, 4-chloroquinoline, 6-chloroquinoline and 4,7-dichloroquinoline by rotating-bomb calorimetry. The Journal of Chemical Thermodynamics doi:10.1016/j.jct.2005.03.011
- Asadollahi et al. (2017). Synthesis and investigation of crystal structure and optical properties of brookite TiO2 nanoparticles capped with (2-chloroquinoline-3-yl) methanol. Journal of Molecular Structure doi:10.1016/j.molstruc.2016.09.032
- Shiri et al. (2016). Highly selective organocatalytic three-component reaction of 2-chloroquinoline-3-carbaldehydes, 6-aminouracils, and cyclic methylene active compounds. Tetrahedron Letters doi:10.1016/j.tetlet.2016.10.057
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