TCI B6777 (CAS 1402232-95-4) is the 5'-fluoro positional isomer within the Boc-protected spiro[piperidine-quinoline] building block family. Its rigid spirocyclic framework combines a piperidine and a tetrahydroquinoline unit, delivering high three-dimensional character for drug discovery work. Paired with the 7'-fluoro analogue, it helps chemists map how fluorine placement influences physicochemical and biological properties. AMI Scientific supplies this TCI reagent in a 100 mg pack size for research laboratories.
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- Mamat et al. (2012). Synthesis and Molecular Structure of tert-Butyl 4-(2-tert-butoxy-2-oxoethyl)piperazine-1-carboxylate. Crystals doi:10.3390/cryst2010090
- Meng et al. (2017). tert-Butyl (2S,3R,4R)-7′-bromo-4-methyl-2′,5-dioxo-4,5-dihydro-3H-spiro[furan-2,3′-indoline]-3-carboxylate. IUCrData doi:10.1107/s2414314617004126
- Hoffmann et al. (1998). Separation of (R)‐ and (S)‐tert‐butyl 2‐tert‐butyl‐4‐methoxy‐2,5‐dihydro‐1,3‐imidazole‐1‐carboxylate (building block for amino acid synthesis) by preparative high performance liquid chromatography on a polysaccharide stationary phase. Chirality doi:10.1002/(sici)1520-636x(1998)10:3<217::aid-chir3>3.3.co;2-r
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
![tert-Butyl 5'-Fluoro-1',4'-dihydro-2'H-spiro[piperidine-4,3'-quinoline]-1-carboxylate (CAS 1402232-95-4) - TCI B6777 - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510B6777.jpg?v=1768816103&width=1445)
