4-Chloro-8-(trifluoromethyl)quinoline TCI C3067

Chemical Identity

CAS No.: 23779-97-7
PubChem: CID 90262·SID 468591057
Formula: C10H5ClF3N
Molecular weight: 231.60 g/mol
Purity: >98.0%(GC)
Reference databases: ECHA

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 4-chloro-8-(trifluoromethyl)quinoline
SMILES: C1=CC2=C(C=CN=C2C(=C1)C(F)(F)F)Cl
InChIKey: LINGICLAECZKAW-UHFFFAOYSA-N
MDL: MDL00134578

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TCI C3067 4-Chloro-8-(trifluoromethyl)quinoline is a heterocyclic starting material that combines a quinoline framework with two functionally important substituents: a chlorine atom at position 4 and a trifluoromethyl group at position 8. The compound belongs to the fluorinated building block family, a category whose demand continues to grow alongside expanding research in medicinal chemistry, agrochemicals, and functional materials. In the laboratory, materials of this type serve as an efficient shortcut for introducing fluorinated groups into target molecules, because installing a trifluoromethyl group directly at a late synthetic stage is generally far more difficult and expensive.

The properties that make this compound a widely preferred choice lie in the two complementary roles of its substituent groups. The chlorine at position 4 of the quinoline ring is an electrophilic site activated by the ring nitrogen, so it reacts readily with nucleophiles such as amines, alkoxides, and thiolates. The trifluoromethyl group, meanwhile, is strongly electron-withdrawing, increases lipophilicity, and is well known for its ability to strengthen the metabolic stability of the final molecule. Together, this combination allows researchers to construct series of compounds built around a fluorinated core.

In Indonesian laboratories, this material is typically handled in university research groups, chemistry departments, and institutional or industrial research units working on synthetic organic chemistry. It is generally used at the bench scale for exploratory reaction development and for preparing intermediates that are carried forward into subsequent synthetic steps. Because it functions as a starting material rather than an end product, it is normally stocked as part of a broader building block inventory supporting ongoing synthesis programmes.

Related TCI products

Medicinal chemistry intermediate synthesis — the activated 4-chloro position allows straightforward displacement by amine nucleophiles, giving rapid access to 4-aminoquinoline analogues carrying a fluorinated core.
Fluorinated building block incorporation — provides a pre-installed trifluoromethyl group, avoiding the difficulty and expense of introducing that group directly during late-stage synthesis of a target molecule.
Agrochemical research and development — the electron-withdrawing trifluoromethyl group and reactive chlorine site support the preparation of candidate structures explored in agrochemical discovery programmes.
Nucleophilic aromatic substitution studies — the ring nitrogen activates the C-4 chlorine toward alkoxides and thiolates, making the compound a practical substrate for substitution chemistry investigations.
Functional materials chemistry — the quinoline scaffold combined with a strongly electron-withdrawing substituent is useful when preparing fluorinated heterocyclic structures for functional materials research.

Brand	TCI (Tokyo Chemical Industry)
CAS number	23779-97-7
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Fluorinated Building Blocks
Pack sizes	—
Physical form	—
Storage	store according to the conditions stated on the manufacturer's label and Safety Data Sheet

Chemical Name: 4-Chloro-8-(trifluoromethyl)quinoline
Product Code: C3067

Store the container tightly closed in a cool, dry, well-ventilated place away from direct sunlight, heat sources, and incompatible materials, following the storage conditions stated on the manufacturer's label and Safety Data Sheet. Keep the material in its original supplier container, or in a clean, chemically compatible, clearly labelled container if transferred. Handle in a fume hood using appropriate personal protective equipment, including gloves, safety goggles, and a laboratory coat. Avoid inhalation of dust or vapour and avoid contact with skin and eyes. Review the Safety Data Sheet before first use, and dispose of residues and contaminated materials through the laboratory's chemical waste procedures.

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