• 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole (CAS 84163-77-9) - TCI F0735 - AMI Scientific
  • 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole (CAS 84163-77-9) - TCI F0735 - AMI Scientific
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TCI

CAS 84163-77-9

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole TCI F0735

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole TCI F0735
Rp 2.598.750,00
Rp 2.598.750,00
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TCI F0735 is 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole, a heterocyclic compound that combines a fluorinated benzisoxazole core with a piperidine ring attached at the third position. This scaffold is widely recognised among medicinal chemistry researchers as a structural motif that appears in active compounds of the antipsychotic class. In the laboratory, the compound generally serves as an advanced synthetic intermediate: the free piperidine nitrogen provides a connection point for installing side chains, so the route toward a target molecule can be shortened meaningfully compared with building the heterocyclic core from scratch.

The property that makes this material valuable is the combination of a rigid aromatic core with a flexible, basic aliphatic ring. The benzisoxazole core supplies a planar, stable framework that governs molecular orientation, while the piperidine ring contributes basic character together with a reaction point that is easy to control. The piperidine nitrogen is nucleophilic, so it is ready to undergo alkylation or reductive amination without disturbing the isoxazole ring. The fluorine atom on the benzene ring improves metabolic stability and modulates lipophilicity, two factors that matter for compounds designed to act in biological systems.

In Indonesian laboratories, this building block is typically used in university and institutional research groups working on organic synthesis and medicinal chemistry, as well as in pharmaceutical development laboratories that prepare reference compounds and analogue series. Because the heterocyclic core arrives already assembled, working groups can focus their bench time on the derivatisation steps that actually differentiate their target molecules, which suits the scale and schedule of most academic and industrial research projects here.

  • Advanced synthetic intermediate preparation — the assembled fluorinated benzisoxazole core removes several construction steps, letting chemists begin work directly at the derivatisation stage of a synthetic route.
  • N-alkylation chemistry — the free, nucleophilic piperidine nitrogen readily accepts alkyl side chains under standard conditions, while the isoxazole ring remains untouched throughout the transformation.
  • Reductive amination studies — the secondary amine of the piperidine ring is a suitable partner for reductive amination, giving researchers a controlled and reliable route for installing varied substituents.
  • Medicinal chemistry analogue synthesis — as a motif found in antipsychotic-class active compounds, this scaffold supports the preparation of structural analogue series for structure–activity relationship investigations.
  • Fluorinated building block research — the aromatic fluorine substituent allows study of how fluorination influences metabolic stability and lipophilicity within a defined and reproducible heterocyclic framework.

Brand TCI
CAS number 84163-77-9
Molecular formula —
Purity —
Category Chemistry > Building Blocks > Fluorinated Building Blocks
Pack sizes available in standard TCI research-scale packaging; please confirm the size required when ordering
Physical form —
Storage keep in the closed original container under the conditions stated on the product label and accompanying documentation
  • Chemical name: 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole

Store the container tightly closed in a cool, dry, well-ventilated area away from direct sunlight, heat sources, and incompatible materials, following the conditions indicated on the product label and safety data sheet. Keep the material in its original supplier container, or transfer it to a chemically compatible, clearly labelled vessel with a secure closure. Handle in a fume hood using safety glasses, gloves, and a laboratory coat, and avoid generating dust or inhaling vapours. Close the container promptly after weighing to limit moisture uptake, and dispose of residues and contaminated consumables through the laboratory's chemical waste procedure.

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