TCI C0284 8-Chloroquinoline (CAS 611-33-6) bears a chlorine atom at the peri position next to the ring nitrogen, giving it a distinctive steric and electronic profile. This substitution pattern relates it structurally to the well-known 8-substituted quinoline chelators, making it a practical starting point for ligand synthesis. The chlorine can be retained as an electron-withdrawing group or converted through palladium-catalysed cross-coupling into aryl, alkenyl, or amino substituents. AMI Scientific offers this TCI heterocyclic building block in 5 g and 25 g packs for synthetic and coordination chemistry laboratories.
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- da Silva et al. (2006). Standard molar enthalpies of formation of 2-chloroquinoline, 4-chloroquinoline, 6-chloroquinoline and 4,7-dichloroquinoline by rotating-bomb calorimetry. The Journal of Chemical Thermodynamics doi:10.1016/j.jct.2005.03.011
- Raj et al. (2014). 1H-1,2,3-Triazole-tethered isatin-7-chloroquinoline and 3-hydroxy-indole-7-chloroquinoline conjugates: Synthesis and antimalarial evaluation. Bioorganic & Medicinal Chemistry Letters doi:10.1016/j.bmcl.2013.12.109
- Peng et al. (2002). ChemInform Abstract: Synthesis of Pyrazole Derivatives 4(1H)‐Quinolone and 4‐Chloroquinoline by Thermolysis of Arylaminomethylene Meldrum′s Acid Derivative.. ChemInform doi:10.1002/chin.200231158
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