Diethyl 1,1-cyclobutanedicarboxylate is a malonate-type diester in which both ester groups sit on a single quaternary carbon of a strained four-membered ring. Hydrolysis followed by decarboxylation provides a classical route to cyclobutanecarboxylic acid derivatives, an increasingly popular motif for adding three-dimensional character to drug candidates. The ester groups can equally be reduced to diols or converted to amides, making the compound a flexible entry point into substituted and spirocyclic cyclobutanes. TCI supplies this liquid in 5 mL and 25 mL packs; handle it in a fume hood and store it tightly closed in a cool, dry, well-ventilated area.
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