Pembayaran hanya melalui request quotation dan dilakukan setelah tim kami menghubungi Anda. Mohon cantumkan nomor WhatsApp aktif untuk konfirmasi pesanan & pembuatan invoice. Estimasi pengiriman 4-5 minggu setelah pembayaran.
Description
TCI D2626 3,5-Difluorobenzaldehyde is a fluorinated aromatic aldehyde in which two fluorine atoms are arranged symmetrically at the meta positions relative to the aldehyde group. This symmetrical arrangement produces a molecule with predictable reactivity, which is why it is widely used as a starting material in directed organic synthesis. In research laboratories, this compound is a common choice when investigators want to introduce a fluorine-bearing aromatic ring into the structure of a target compound, whether for pharmaceutical research, agrochemical materials, or the development of functional organic molecular materials.
The advantages of this compound come from the combination of a reactive aldehyde group with the electronic effects of the fluorine atoms. The aldehyde group is ready to undergo reductive amination, condensation to form imines, Wittig as well as Horner–Wadsworth–Emmons reactions, organometallic addition, and oxidation to the corresponding carboxylic acid. The two electron-withdrawing fluorine atoms increase the electrophilicity of the carbonyl group, so many reactions proceed more smoothly. The symmetrical 3,5-substitution pattern leaves the para position relatively open and reduces the likelihood of forming regioisomer mixtures, so reaction outcomes are cleaner and easier to purify.
In Indonesian laboratories, this building block is typically used in university and institutional research groups working on medicinal chemistry, agrochemical intermediates, and organic materials, where a reliable fluorinated aromatic aldehyde is needed for multi-step synthetic routes. It is also suited to method development and small-scale route scouting, where predictable reactivity keeps results reproducible between batches and allows a synthetic sequence to be repeated by different researchers with consistent outcomes.
Laboratory Applications
- Reductive amination routes — the reactive aldehyde group condenses readily with amines and is then reduced, giving direct access to fluorinated benzylamine structures for medicinal chemistry programmes.
- Imine and Schiff base formation — condensation with primary amines proceeds smoothly because the fluorine atoms raise carbonyl electrophilicity, supporting ligand synthesis and organic materials research.
- Wittig and Horner–Wadsworth–Emmons olefination — the aldehyde serves as the carbonyl partner for building fluorinated styrene and cinnamate-type frameworks in directed synthesis.
- Organometallic addition chemistry — addition of organolithium or Grignard reagents to the activated carbonyl produces substituted fluorinated benzyl alcohols as advanced synthetic intermediates.
- Oxidation to carboxylic acid — straightforward conversion of the aldehyde provides 3,5-difluorobenzoic acid derivatives used as fluorinated acid building blocks for further coupling.
Specifications
- Brand: TCI
- CAS number: 32085-88-4
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Chemical class: fluorinated aromatic aldehyde with fluorine atoms at the 3 and 5 positions
- Pack sizes: available in standard TCI research-scale packaging; please confirm the size required when ordering
- Storage note: store in a tightly closed original container in a cool, dry, well-ventilated place away from ignition sources and incompatible materials
Handling and Storage
Keep this material in its tightly closed original container in a cool, dry and well-ventilated storage area, away from direct sunlight, heat and sources of ignition. Amber glass or the supplied container is preferred, since aromatic aldehydes are sensitive to air and can oxidise over time; reseal promptly after each use and minimise headspace where practical. Handle in a functioning fume hood using gloves, safety glasses and a laboratory coat, and avoid inhalation of vapours or contact with skin and eyes. Store separately from strong oxidising agents, strong bases and amines. Dispense with clean, dry glassware, label all working solutions clearly, and dispose of residues and contaminated materials through the laboratory's chemical waste route. Always consult the manufacturer's safety data sheet before first use.
![[1,1'-Biphenyl]-2-carboxaldehyde (CAS 1203-68-5) - TCI B6334 - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510B6334.jpg?v=1768816032&width=533)
