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Description
TCI D2637 2,5-Difluorobenzaldehyde, bearing CAS number 2646-90-4, is an aromatic aldehyde whose benzene ring carries two fluorine atoms at the 2 and 5 positions. The compound belongs to the family of fluorinated building blocks, that is, starting materials prepared specifically for introducing fluorine atoms into the framework of a target molecule. In the synthesis laboratory, the aldehyde group serves as a highly versatile point of entry for reaction, ranging from condensation with amines to form imines, nucleophilic addition reactions, and reduction to the corresponding benzylic alcohol, through to oxidation to the carboxylic acid, so that this single starting material can lead researchers toward several different classes of derivative at once.
The property that makes this compound such a frequent choice is the strong electronic influence of the two fluorine atoms, which withdraw electron density from the aromatic ring. That effect increases the electrophilicity of the carbonyl carbon, so addition reactions proceed more smoothly, while at the same time activating the ring toward nucleophilic aromatic substitution at the appropriate positions. The presence of fluorine is also well known for adding value to the final molecule, because it frequently improves metabolic stability, solubility, and binding strength at a biological target. The substitution pattern therefore gives the chemist both reliable reactivity and a predictable handle on where subsequent bond formation will occur.
In Indonesian laboratories, a fluorinated building block of this kind is typically used in university and institutional research settings as well as in industrial research and development. It supports organic synthesis groups preparing derivative libraries, medicinal chemistry work exploring fluorine substitution on candidate scaffolds, and materials chemistry projects where fluorine content is deliberately designed in. Because the material is supplied by TCI, it fits established laboratory practice of using a documented, consistently sourced reagent for work that must be repeatable across batches and across research groups.
Laboratory Applications
- Imine and Schiff base formation — condensation of the aldehyde group with primary amines proceeds readily because the fluorine substituents raise carbonyl electrophilicity, giving cleaner access to imine intermediates for further transformation.
- Medicinal chemistry scaffold construction — the fluorinated ring is carried through into the final molecule, where fluorine substitution is known to improve metabolic stability, solubility, and binding strength at biological targets.
- Nucleophilic aromatic substitution chemistry — the electron-withdrawing fluorine atoms activate the aromatic ring so that nucleophiles can displace substituents at the appropriate positions under controlled synthetic conditions.
- Reduction and oxidation route development — the aldehyde can be reduced to the benzylic alcohol or oxidized to the carboxylic acid, letting one starting material serve several derivative classes.
- Nucleophilic addition and derivative library synthesis — the activated carbonyl carbon accepts a wide range of nucleophiles, making the compound a practical entry point for building structurally related compound series.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- CAS Number: 2646-90-4
- Catalogue Number: D2637
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Pack Sizes: available in standard TCI research and laboratory-scale packaging; please confirm the size required when ordering
- Storage: keep in the tightly closed original container in a cool, dry, well-ventilated place away from light and incompatible materials
Handling and Storage
Store the material in its original tightly closed container in a cool, dry, well-ventilated area, protected from direct sunlight and kept away from oxidizing agents, strong acids, strong bases, and amines, with which the aldehyde group can react. Amber glass or the manufacturer's supplied container is preferred, and the cap should be closed promptly after each use to limit exposure to air and moisture. Handle in a fume hood using appropriate personal protective equipment, including safety glasses, chemically resistant gloves, and a laboratory coat, and avoid inhalation of vapour and contact with skin and eyes. Transfer with clean, dry glassware, label all secondary containers clearly, and consult the manufacturer's Safety Data Sheet before use and for waste disposal guidance in accordance with local laboratory regulations.
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