2,4-Difluorophenylhydrazine Hydrochloride TCI D2698

Name: TCI D2698 51523-79-6 2,4-Difluorophenylhydrazine Hydrochloride
Brand: TCI
SKU: TCI2510D269823010
Price: 2126250.0 IDR
Availability: InStock

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Berat 5g 25g

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Description

TCI D2698 2,4-Difluorophenylhydrazine Hydrochloride is a synthesis chemical from TCI that belongs to the fluorinated building block group. The compound is the hydrochloride salt of an arylhydrazine bearing two fluorine atoms at positions 2 and 4 of the benzene ring. In the laboratory, arylhydrazines are key reagents for constructing nitrogen-containing heterocyclic rings, so this material serves as a primary entry point toward indoles, pyrazoles, triazoles, indazoles, and a wide range of hydrazones. The salt form is chosen specifically to make storage and handling easier compared with the free arylhydrazine base, which is considerably more sensitive.

The property that makes this material a frequent choice is the combination of hydrazine group reactivity with the influence of the two fluorine atoms on the aromatic ring. The hydrazine group is doubly nucleophilic, so it reacts readily with carbonyl compounds to form hydrazones, which can subsequently be cyclized into heterocyclic cores. The fluorine atoms make an important contribution to modern molecular design because they alter local electronegativity, metabolic stability, and the lipophilicity of the target molecule. Meanwhile, the hydrochloride form yields a crystalline solid that is more stable toward oxidation and easier to weigh accurately.

In Indonesian laboratories, this building block is typically used in organic synthesis and medicinal chemistry research groups at universities and research institutes, as well as in process development work where fluorinated heterocyclic cores are required. It fits routine bench-scale synthesis: weighing out a defined quantity of the crystalline salt, liberating the free hydrazine in situ with a base, and carrying the reaction forward to the desired heterocycle. The stable salt form suits laboratories that store reagents over longer periods in warm, humid tropical conditions.

Laboratory Applications

Fischer indole synthesis — the arylhydrazine condenses with a ketone or aldehyde to give a hydrazone that cyclizes into a difluorinated indole core used widely in medicinal chemistry programmes.
Pyrazole ring construction — the doubly nucleophilic hydrazine group reacts with 1,3-dicarbonyl compounds, delivering fluorine-substituted pyrazoles in a single, well-established condensation step suitable for routine bench work.
Indazole and triazole preparation — this reagent introduces the nitrogen–nitrogen unit required for these heterocyclic scaffolds while simultaneously installing the 2,4-difluorophenyl substituent on the ring system.
Hydrazone formation and carbonyl derivatisation — the hydrazine reacts cleanly with aldehydes and ketones to give crystalline hydrazones, useful both as synthetic intermediates and as characterisation derivatives.
Fluorinated intermediate synthesis for drug discovery — the two ring fluorines tune electronegativity, metabolic stability, and lipophilicity, making this a practical starting material for structure–activity relationship studies.

Specifications

Brand: TCI
CAS Number: 51523-79-6
Category: Chemistry > Building Blocks > Fluorinated Building Blocks
Product Code: D2698
Physical Form: crystalline solid (hydrochloride salt)
Pack Sizes: available in standard TCI laboratory pack sizes; please confirm the size required when ordering
Storage: keep in a tightly closed container, protected from moisture

Handling and Storage

Store the material in its original tightly closed container in a cool, dry, well-ventilated area, away from moisture, direct sunlight, and sources of ignition. Amber glass or the supplier's original packaging is suitable, and the container should be resealed promptly after each use because the salt is hygroscopic in humid conditions. Handle in a fume hood using nitrile gloves, safety goggles, and a laboratory coat, since arylhydrazines are irritant and should not contact skin or eyes. Keep the compound away from strong oxidising agents and strong bases, which may liberate the more sensitive free hydrazine. Weigh out only the quantity required, and dispose of residues and contaminated consumables through the laboratory's chemical waste stream in line with the manufacturer's safety data sheet.