Pembayaran hanya melalui request quotation dan dilakukan setelah tim kami menghubungi Anda. Mohon cantumkan nomor WhatsApp aktif untuk konfirmasi pesanan & pembuatan invoice. Estimasi pengiriman 4-5 minggu setelah pembayaran.
Description
TCI D3406 2,5-Difluorobenzoyl Chloride is a fluorinated aromatic acyl chloride carrying two fluorine atoms at the 2- and 5-positions of the benzene ring. As a fluorinated building block, it is used to introduce a fluorinated benzoyl fragment into target molecules through acylation reactions. The acyl chloride group is one of the most reactive carboxylic acid derivatives, so its reaction with amines gives amides and its reaction with alcohols or phenols gives esters rapidly, generally under mild conditions with the help of an acid-scavenging base such as triethylamine or pyridine.
The property that makes this compound a preferred choice is the influence of its two fluorine atoms on the behaviour of the resulting molecule. Fluorine is highly electronegative yet small in size, so its addition raises the electron-withdrawing character of the ring without adding significant steric bulk. In active-ingredient research, fluorinated aryl fragments frequently improve metabolic stability, tune the acidity of neighbouring groups, and enhance interactions with biological targets. The fluorine at the ortho position also activates the ring toward nucleophilic aromatic substitution, opening further cyclisation routes after the acylation step.
In Indonesian laboratories, this reagent is typically used in synthetic organic chemistry groups at universities and research institutes, as well as in pharmaceutical and agrochemical development work where a fluorinated benzoyl fragment must be attached to an intermediate. It suits bench-scale route development, medicinal chemistry analogue series, and preparation of reference intermediates, where the high reactivity of the acyl chloride shortens reaction times and simplifies the workup compared with activating a free carboxylic acid in situ.
Laboratory Applications
- Amide bond formation — reaction with primary or secondary amines proceeds rapidly under mild conditions with an acid-scavenging base, making it a direct route to fluorinated benzamide intermediates.
- Ester and aryl ester synthesis — coupling with alcohols or phenols gives the corresponding esters quickly, because the acyl chloride is far more reactive than the parent carboxylic acid.
- Medicinal chemistry analogue series — the fluorinated aryl fragment often improves metabolic stability and target interaction, so it is valuable when preparing sets of related candidate structures for evaluation.
- Nucleophilic aromatic substitution and cyclisation — the ortho fluorine activates the ring toward displacement, allowing further ring-closing steps to be carried out after the initial acylation.
- Fluorinated intermediate preparation for agrochemical research — introducing an electron-withdrawing difluorobenzoyl unit tunes the acidity of neighbouring groups without adding meaningful steric bulk to the scaffold.
Specifications
- Brand: TCI
- CAS number: 35730-09-7
- Product code: D3406
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Pack sizes: available in the standard research pack sizes offered by the manufacturer; please confirm the size required when ordering
- Storage: keep in a tightly closed container in a cool, dry place away from moisture
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated place, kept clearly away from water, moist air, alcohols, amines, and bases, since acyl chlorides react readily with such substances. Use the original manufacturer container or a compatible, well-sealed glass container, and reseal promptly after each transfer to limit exposure to atmospheric moisture. Handle in a fume hood with appropriate gloves, safety glasses, and a laboratory coat, transfer with dry glassware, and neutralise residues and rinsings according to your institution's chemical waste procedures. Always consult the manufacturer's safety data sheet before use.
![[1,1'-Biphenyl]-2-carbonyl Chloride (CAS 14002-52-9) - TCI B6543 - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510B6543.jpg?v=1767093866&width=533)
![Ethyl [1,1'-Biphenyl]-4-carboxylate (CAS 6301-56-0) - TCI B6587 - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510B6587.jpg?v=1767093973&width=533)
