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Description
TCI D3441 2,4-Difluorobenzyl Cyanide, also known as 2,4-difluorophenylacetonitrile, is a fluorinated building block that combines a benzene ring bearing two fluorine substituents with an acetonitrile group. This simple structure holds two important centres of reactivity: the nitrile group, which can be hydrolysed to a carboxylic acid or reduced to a primary amine, and the adjacent benzylic carbon, which is sufficiently acidic to be deprotonated and alkylated with ease. That combination makes it a starting material that appears frequently in synthetic routes toward active pharmaceutical compounds and agrochemical materials in research laboratories.
The property that makes this compound a preferred choice lies in the 2,4-fluorination pattern on the aromatic ring. Fluorine is highly electronegative yet small in size, so its presence alters electron distribution, the acidity of the benzylic protons, and the metabolic stability of the final molecule without adding meaningful steric bulk. The ortho and para positions relative to the side chain deliver an electron-withdrawing effect that is felt directly in the reactivity of the carbanion that forms. In addition, the nitrile group serves as a flexible masked functional group, since it can be carried through several steps and then converted as the route requires.
In Indonesian laboratories, this material is typically used at the bench scale in university and institutional research groups working on medicinal chemistry and agrochemical intermediates, as well as in industrial R&D units developing new synthetic routes. It is normally ordered as a catalogue building block for exploratory reaction screening, small-scale multi-step synthesis, and method development work, where a well-defined fluorinated starting material saves the effort of preparing the fragment in house.
Laboratory Applications
- Pharmaceutical intermediate synthesis: the nitrile and acidic benzylic carbon give two independent handles, letting researchers build fluorinated drug-like scaffolds through short, controllable synthetic sequences.
- Agrochemical building block work: the 2,4-difluoro pattern is a recurring motif in crop-protection chemistry, so this material serves as a direct entry point into candidate structures.
- Benzylic alkylation chemistry: the proton alpha to the nitrile is easily removed by base, and the resulting carbanion reacts cleanly with alkylating agents to extend the side chain.
- Primary amine preparation: reduction of the nitrile group provides access to 2,4-difluorophenethylamine-type fragments that are valuable in medicinal chemistry building block libraries.
- Carboxylic acid route development: hydrolysis of the nitrile converts this compound into the corresponding arylacetic acid, a common intermediate for amide and ester coupling studies.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- CAS Number: 656-35-9
- Catalogue Number: D3441
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Pack Sizes: available in standard TCI research-scale catalogue pack sizes; please confirm the currently listed options when ordering
- Storage: keep in a cool, dry, well-ventilated place in a tightly closed original container, away from light and incompatible materials
Handling and Storage
Store this product in its original tightly closed container in a cool, dry, and well-ventilated area, protected from direct sunlight and kept away from strong oxidising agents, strong bases, and sources of ignition. Chemically resistant glass bottles with secure closures are appropriate for storage and for any subdivided working quantities, which should be clearly labelled. Handle the material inside a fume hood using nitrile gloves, safety glasses, and a laboratory coat, since nitriles can be harmful on inhalation or skin contact. Avoid generating aerosols, keep containers closed when not in active use, and collect residues as designated chemical waste. Always consult the manufacturer's current Safety Data Sheet before use and follow your institution's local handling procedures.
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