2,8-Dihydroxyquinoline TCI D3819

Name: TCI D3819 15450-76-7 2,8-Dihydroxyquinoline
Brand: TCI
SKU: TCI2510D381924205
Price: 1240050.0 IDR
Availability: InStock

Rp 1.240.050,00

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Berat 5g 25g

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Description

TCI D3819 with CAS number 15450-76-7 is 2,8-Dihydroxyquinoline, a heterocyclic compound built on a quinoline framework that carries hydroxy groups at the second and eighth positions. The compound belongs to the class of heterocyclic building blocks, meaning nitrogen-containing ring starting materials that serve as the point of departure for the construction of more complex molecules. The quinoline skeleton itself is one of the most frequently encountered motifs in medicinal chemistry, which makes its hydroxylated derivatives valuable materials for organic synthesis laboratories as well as for drug discovery research laboratories.

The characteristic that makes this compound particularly attractive is the combination of two hydroxy groups occupying positions of distinctly different character. The hydroxy group at position two sits adjacent to the ring nitrogen and can undergo tautomerism into the keto form, that is, the quinolin-2(1H)-one or carbostyril framework, so that the compound offers dual reactivity depending on the reaction conditions applied. The hydroxy group at position eight, meanwhile, lies close to the nitrogen atom and thereby forms the characteristic donor pair for binding metal ions, as is well known throughout the 8-hydroxyquinoline family. Both hydroxy groups additionally provide points for further functionalisation.

In Indonesian laboratories, this type of heterocyclic building block is typically held as a working reagent by university and institutional synthetic chemistry groups, by drug discovery research units, and by coordination chemistry laboratories. It is normally ordered in the modest pack sizes appropriate to multi-step synthesis work, where a single small quantity supports repeated trial reactions, route scouting, and derivative preparation rather than production-scale processing. Supplying it as a TCI catalogue item allows research groups to work from a consistently identified starting material across a project.

Laboratory Applications

Heterocyclic synthesis starting material: the quinoline core with two reactive hydroxy handles allows chemists to build more complex nitrogen heterocycles through stepwise, controlled functionalisation of each position.
Medicinal chemistry and drug discovery scouting: because quinoline is among the most common motifs in medicinal chemistry, this hydroxylated derivative serves research groups preparing and screening candidate analogue series.
Metal ion coordination studies: the hydroxy group at position eight together with the neighbouring ring nitrogen forms the classic donor pair of the 8-hydroxyquinoline family for binding metal ions.
Tautomerism and reactivity investigations: the position-two hydroxy group can shift into the quinolin-2(1H)-one or carbostyril keto form, giving teaching and research laboratories a clear model of condition-dependent dual reactivity.
Derivative and intermediate preparation: both hydroxy groups act as functionalisation points, so laboratories can convert the material into ethers, esters, or other substituted quinoline intermediates for onward routes.

Specifications

Brand: TCI (Tokyo Chemical Industry)
CAS number: 15450-76-7
Chemical name: 2,8-Dihydroxyquinoline
Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
Pack sizes: available in the research-scale catalogue pack sizes offered by TCI for this item; please confirm the specific size when ordering
Storage: keep in the tightly closed original container as indicated on the manufacturer label

Handling and Storage

Store the material in its original tightly closed container, kept in a cool, dry, well ventilated place away from direct sunlight, moisture, and incompatible chemicals. Amber glass or the manufacturer's supplied container is suitable, since hydroxylated aromatic compounds are generally handled with protection from light and air. Weigh and transfer the solid inside a fume hood using clean, dry spatulas to avoid contaminating the bulk stock. Laboratory personnel should wear safety glasses, gloves, and a laboratory coat, avoid inhalation of dust, and follow the manufacturer's safety data sheet for detailed exposure and disposal guidance. Return the container promptly to its designated storage location after use, and record each withdrawal so that reagent identity and history remain traceable throughout the project.