4-(Difluoromethoxy)benzenesulfonamide TCI D4778

Name: TCI D4778 874781-09-6 4-(Difluoromethoxy)benzenesulfonamide
Brand: TCI
SKU: TCI2510D477825478
Price: 1888950.0 IDR
Availability: InStock

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Berat 1g 5g

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Description

TCI D4778 4-(Difluoromethoxy)benzenesulfonamide is a fluorinated building block that combines an aromatic sulfonamide group with a difluoromethoxy substituent at the para position. Both of these functional groups are highly valued in medicinal chemistry: the sulfonamide is a classical pharmacophore that appears across many drug classes, while the difluoromethoxy group is used to tune the lipophilicity and metabolic stability of a molecule. In the synthetic laboratory, this compound serves as a ready-to-use intermediate that saves several fluorination and sulfonylation steps which are normally complicated and require specialised reagents.

The properties that make this material a preferred choice are the strong electronic effects of the OCF2H group, which is electron-withdrawing while also able to act as a weak hydrogen bond donor — a combination that an ordinary methoxy group cannot reproduce. The strong carbon–fluorine bonds give high resistance to oxidative degradation, so derivatives prepared from it tend to be more metabolically stable. The primary sulfonamide group on this material provides a nucleophilic nitrogen atom that can be acylated, alkylated, or used in coupling reactions, and at the same time acts as an anchoring group for further molecular elaboration.

In Indonesian laboratories, a building block of this type is typically used in university and institutional research groups working on medicinal chemistry and organic synthesis, as well as in formulation and analytical development laboratories that require well-defined intermediates. Because it removes the need to run difficult fluorination chemistry in-house, it suits laboratories that have limited access to specialised fluorinating reagents and dedicated handling facilities, and it supports small-scale exploratory synthesis and structure–activity studies.

Laboratory Applications

Medicinal chemistry scaffold synthesis — the sulfonamide pharmacophore combined with a para difluoromethoxy group provides a starting point for building drug-like candidate molecules without extra fluorination steps.
Metabolic stability optimisation — the strong carbon–fluorine bonds resist oxidative degradation, so this block is used when researchers need derivatives that are less prone to metabolic breakdown.
Lipophilicity tuning studies — the difluoromethoxy substituent lets chemists adjust the lipophilic character of a target molecule in a controlled way during structure–activity relationship work.
Sulfonamide derivatisation chemistry — the primary sulfonamide nitrogen is nucleophilic and can be acylated, alkylated, or carried into coupling reactions to extend the molecular framework further.
Fluorinated intermediate supply for multi-step synthesis — using this ready-made intermediate avoids the complicated sulfonylation and fluorination sequences that normally demand specialised reagents and handling.

Specifications

Brand: TCI (Tokyo Chemical Industry)
Product code: D4778
CAS number: 874781-09-6
Chemical name: 4-(Difluoromethoxy)benzenesulfonamide
Category: Chemistry > Building Blocks > Fluorinated Building Blocks
Pack sizes: available in standard TCI research-scale packaging; please confirm the current pack options when ordering
Storage: keep in the tightly closed original container in a cool, dry place, following the manufacturer's storage statement on the label

Handling and Storage

Store the material in its tightly closed original container in a cool, dry, well-ventilated area, away from heat sources, direct sunlight, moisture, and incompatible chemicals such as strong oxidising agents and strong bases. Amber glass or the supplied manufacturer's container is suitable; transfer only into clean, dry, chemically compatible and clearly labelled vessels. Handle in a fume hood using standard personal protective equipment — safety glasses, nitrile gloves, and a laboratory coat — and avoid generating dust or inhaling the powder. Weigh quickly and reseal promptly to limit moisture uptake. Keep the manufacturer's safety data sheet accessible, and always follow it together with your institutional chemical waste and disposal procedures.