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Description
TCI E0051 3-Ethoxyphenol is a substituted phenol carrying an ethoxy group at the meta position relative to the hydroxyl group. This arrangement makes it a valuable starting material in organic synthesis, because the two electron-donating groups on the benzene ring exert a characteristic directing influence over where subsequent substitution reactions will proceed. In the laboratory, the compound is used to build larger aromatic frameworks, to prepare phenolic ether and ester derivatives, and as an intermediate in the synthesis of active compounds that require a meta substitution pattern which is difficult to obtain by other routes.
The property that makes this material a preferred choice is the predictability of its reactions. The phenolic hydroxyl group is sufficiently acidic that it is readily converted into a phenoxide for alkylation and acylation reactions, while the ethoxy group persists as a stable, directing substituent. Researchers can therefore introduce new groups at positions that can be anticipated in advance, which saves a considerable amount of time at the purification stage. The material also belongs to the class of intermediates that are not commonly available in ready-to-use form, so the availability of a synthesis-grade product from TCI spares the laboratory from having to prepare it in house.
In Indonesian laboratories, 3-Ethoxyphenol is typically used in university research groups and industrial research and development units working on organic synthesis, medicinal chemistry, and materials chemistry. It usually appears in small-scale reaction work where a specific meta-substituted aromatic building block is required and where preparing the intermediate locally would consume time and reagents better spent on the target molecule itself. Reliable supply of a synthesis-grade material lets a project move directly to the reaction step.
Laboratory Applications
Construction of larger aromatic frameworks, where the meta relationship between the hydroxyl and ethoxy substituents fixes the ring geometry needed for the target scaffold.
Preparation of phenolic ether derivatives, since the acidic hydroxyl group is easily deprotonated to a phenoxide that undergoes clean alkylation with common alkylating agents.
Preparation of phenolic ester derivatives through acylation of the hydroxyl group, with the ethoxy substituent remaining intact and unreactive throughout the transformation.
Intermediate work in the synthesis of active compounds that specifically require a meta substitution pattern, which is otherwise difficult to install by direct routes.
Directed substitution studies in synthetic methodology work, where the two electron-donating groups make the position of further substitution predictable and reduce purification effort.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS number: 621-34-1
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Product code: E0051
Grade: synthesis grade, suitable for organic synthesis work
Pack sizes: available in standard TCI research pack sizes; please confirm the currently offered size when ordering
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated place, away from direct sunlight, heat sources, and strong oxidising agents. Keep the material in its original supplier container, or in a clean amber glass bottle with a chemically resistant closure, since phenolic compounds are generally sensitive to prolonged exposure to light and air. Handle only in a fume hood, wearing safety glasses, nitrile gloves, and a laboratory coat, as phenols may irritate the skin, eyes, and respiratory tract. Avoid direct skin contact and inhalation of vapour, label all working solutions clearly, and consult the manufacturer's safety data sheet before first use and for disposal of residues.
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