Pembayaran hanya melalui request quotation dan dilakukan setelah tim kami menghubungi Anda. Mohon cantumkan nomor WhatsApp aktif untuk konfirmasi pesanan & pembuatan invoice. Estimasi pengiriman 4-5 minggu setelah pembayaran.
Description
TCI F0620, CAS 115029-23-7, is 2-Fluoro-5-(trifluoromethyl)benzoic Acid, a fluorinated benzoic acid isomer carrying a fluorine atom at the ortho position and a trifluoromethyl group at the para position relative to that fluorine. The compound serves as a building block in organic synthesis, particularly for preparing aromatic carboxylic acid derivatives with finely tuned electronic properties. Its role in the laboratory is to supply a ready-to-use aromatic fragment that can be directly coupled, esterified, or converted into reactive intermediates without having to work through the fluorination steps that are typically complicated and expensive.
The characteristic that distinguishes this material from other isomers is the position of the trifluoromethyl group, which alters electron density distribution and molecular geometry and therefore produces a different reactivity profile and target-recognition behaviour. The two fluorinated substituents together withdraw electrons strongly, increasing the acidity of the carboxyl group and making acid derivative formation easier. Aromatic fluorine atoms and trifluoromethyl groups are also recognised for improving metabolic stability, lipophilicity, and the binding strength of a compound toward its target protein.
In Indonesian laboratories, this building block is typically used in synthetic and medicinal chemistry research groups that prepare fluorinated intermediates for screening, as well as in analytical and method-development work where a well-defined aromatic acid standard is required. Because it arrives as a finished fluorinated fragment, it removes the need for in-house fluorination infrastructure, which suits academic and industrial laboratories that want to shorten synthetic routes while keeping structural control over the final molecules.
Laboratory Applications
- Medicinal chemistry intermediate preparation: the fluorine and trifluoromethyl substituents improve metabolic stability and lipophilicity, making it a practical starting fragment for candidate molecules intended to bind target proteins.
- Amide and ester derivative synthesis: the strongly electron-withdrawing substituents raise carboxyl acidity, so activation and conversion into acid derivatives proceed more readily than with unsubstituted benzoic acid analogues.
- Coupling reaction substrate: the compound can be introduced directly into coupling sequences as a prepared aromatic fragment, saving the complicated and costly fluorination stages that would otherwise be required.
- Structure-activity relationship studies: because the trifluoromethyl position changes electron density distribution and molecular geometry, it lets researchers compare isomer effects on reactivity and target recognition systematically.
- Reactive intermediate generation: the aromatic acid is readily transformed into more reactive species for downstream functionalisation, giving synthetic chemists a flexible entry point into fluorinated aromatic chemistry.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- Catalogue number: F0620
- CAS number: 115029-23-7
- Chemical name: 2-Fluoro-5-(trifluoromethyl)benzoic Acid
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Pack sizes: available in standard TCI research-scale packaging; please confirm the currently listed pack options when ordering
- Storage: keep in a cool, dry place in the tightly closed original container
Handling and Storage
Store the container tightly closed in a cool, dry, and well-ventilated area, away from moisture, incompatible materials, and direct sunlight. Keep the material in its original supplier container or in an equivalent chemically resistant, clearly labelled vessel, and reseal it promptly after each use to limit moisture uptake. Handle the compound as an organic acid: work in a fume hood, wear safety glasses, gloves, and a laboratory coat, and avoid contact with skin and eyes as well as inhalation of any dust. Use clean, dry spatulas when weighing to prevent contamination of the stock, and always consult the manufacturer's safety data sheet before use and before disposal of residues.
![[1,1'-Biphenyl]-2-carbonyl Chloride (CAS 14002-52-9) - TCI B6543 - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510B6543.jpg?v=1767093866&width=533)
![Ethyl [1,1'-Biphenyl]-4-carboxylate (CAS 6301-56-0) - TCI B6587 - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510B6587.jpg?v=1767093973&width=533)
