TCI M1021 (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic Acid is a chiral aryl propionic acid built on a methoxylated naphthalene framework, widely known as naproxen, a non-steroidal anti-inflammatory compound that inhibits the cyclooxygenase enzyme. Within the life science line it is classified under enzymes, enzyme inhibitors, and enzyme substrates. In the laboratory the compound serves as a reference material and a research tool, supporting enzyme inhibition assays, the development and validation of analytical methods, and work as a model compound in formulation and active-ingredient release studies.
The properties that make this material important begin with the purity of its S enantiomeric configuration, which determines its biological activity, since chirality plays a major role in recognition by the active site of the enzyme. The carboxylic acid group confers weak acidity and pH-dependent solubility, so its behaviour is readily controlled in buffered systems for both assay and analytical purposes. The conjugated naphthalene core provides ultraviolet absorption and fluorescence characteristics that are useful for detection in high performance liquid chromatography. It is the combination of chirality, an acidic group, and a chromophoric group that gives this compound its value.
In Indonesian laboratories this material is typically used in pharmaceutical research groups, university chemistry and pharmacy departments, and analytical service laboratories that require a well characterised reference compound. It supports enzyme inhibition studies, chromatographic method work, and teaching or research programmes in medicinal chemistry. Because it is a defined chiral standard, it is also drawn upon where separation of enantiomers, buffer-dependent solubility behaviour, or ultraviolet detection must be demonstrated reliably in routine bench work.
- Enzyme inhibition assays: the compound acts as a cyclooxygenase inhibitor, making it a suitable reference inhibitor for evaluating assay response and comparing the behaviour of candidate compounds under the same conditions.
- Analytical method development and validation: its ultraviolet absorption and fluorescence from the conjugated naphthalene core allow straightforward detection in high performance liquid chromatography during method setup and verification work.
- Chiral separation studies: the defined S enantiomeric configuration makes it a practical test compound for demonstrating and optimising enantioselective separation systems and for confirming stereochemical resolution.
- Formulation and release studies: as a model active compound with pH-dependent solubility, it is used to examine dissolution and release behaviour of active ingredients in buffered media.
- Reference material for identity and comparison work: a well characterised chiral aryl propionic acid serves as a comparison standard in medicinal chemistry research and instructional laboratory programmes.
| Brand | TCI |
|---|---|
| CAS number | 22204-53-1 |
| Molecular formula | — |
| Purity | — |
| Category | Life Science > Biochemicals and Reagents > Enzymes, Enzyme Inhibitors, Enzyme Substrates |
| Pack sizes | available in the standard catalogue pack sizes offered by TCI for this item; please confirm the required size when ordering |
| Physical form | — |
| Storage | store according to the conditions stated on the product label and safety data sheet |
- Chemical class: chiral aryl propionic acid with a methoxylated naphthalene framework
Store the container tightly closed in a cool, dry, and well ventilated area, away from direct sunlight, heat sources, and incompatible materials, following the conditions stated on the product label and safety data sheet. Keep the material in its original container or in a chemically compatible, clearly labelled vessel that protects against moisture uptake. Handle in a fume hood using a laboratory coat, safety glasses, and suitable chemical resistant gloves, and avoid generating dust when weighing. Close the container promptly after use, record the opening date, and dispose of residues and contaminated materials in accordance with applicable laboratory waste procedures.
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