Meloxicam TCI M1959

Meloxicam is a nonsteroidal anti-inflammatory compound belonging to the oxicam class, widely recognised as a cyclooxygenase inhibitor with a tendency toward selectivity for the COX-2 isoform. Within the context of a laboratory reagent catalogue, this compound is classified as an enzyme inhibitor intended for research and testing purposes, and not as a finished pharmaceutical preparation. Its role in the laboratory includes serving as a test compound in studies of the prostaglandin pathway, providing a comparative standard in quality analysis of pharmaceutical preparations, and supplying a model substance for formulation research that focuses on compounds with low aqueous solubility.

The characteristics that make meloxicam a frequently chosen material are rooted in its oxicam structure, which contains a benzothiazine ring, an enol group, an amide group, and a methyl-substituted thiazole ring. The combination of these functional groups produces a compound that behaves as a weak acid and is capable of forming intramolecular hydrogen bonds, so that its solubility profile is strongly dependent on the pH of the medium. This property makes it an attractive model substance for research into solubility enhancement, cocrystal formation, and solid dispersion systems. The conjugated system within its structure also gives rise to ultraviolet absorption, a feature that supports spectroscopic and chromatographic detection.

In Indonesian laboratories, meloxicam is typically encountered in pharmaceutical research groups at universities, in quality control units, and in biochemical research settings where enzyme inhibition is the subject of study. It is generally handled as a research-grade catalogue item in small quantities, weighed out for the preparation of stock solutions or reference standards, and documented according to the institution's internal procedures for research chemicals rather than treated as a medicinal product.

• Cyclooxygenase inhibition studies, where meloxicam serves as a reference inhibitor with a known tendency toward COX-2 selectivity, allowing enzyme activity assays to be benchmarked against a well-characterised oxicam compound.
• Prostaglandin pathway research, in which the compound is applied as a test substance to probe how inhibition at the cyclooxygenase step alters downstream mediators within experimental biochemical systems under investigation.
• Comparative standard preparation for pharmaceutical quality analysis, where a defined catalogue-grade material is required to construct calibration series and verify analytical methods applied to finished preparations.
• Solubility enhancement and formulation modelling, taking advantage of the weakly acidic character and pH-dependent solubility profile that make this compound a demanding and therefore informative model substance.
• Cocrystal and solid dispersion research, where the enol, amide, and benzothiazine functional groups provide hydrogen bonding sites suitable for investigating solid-state interactions with selected coformers and carriers.

• Catalogue code: M1959

Store the container in a cool, dry place away from direct sunlight, protected from moisture, and kept tightly closed when not in use, following the conditions stated on the manufacturer's label and safety data sheet. Original supplier packaging is the preferred container; where transfer is necessary, use clean, dry, chemically compatible vessels that are clearly labelled with the compound name and CAS number. Handle the material in a well-ventilated area or within a fume hood when weighing powder, and wear a laboratory coat, gloves, and eye protection. Avoid the generation of dust, and wash hands thoroughly after handling. Dispose of residues and contaminated materials in accordance with the institution's chemical waste procedures.

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