TCI M1027 1-Methylhydantoin is a heterocyclic compound registered under CAS number 616-04-6, built around a hydantoin ring — an imidazolidine-2,4-dione framework carrying a methyl group bonded to the nitrogen atom at position one. In organic synthesis laboratories, this compound serves as a heterocyclic building block that provides a five-membered scaffold bearing two carbonyl groups and one free nitrogen that remains available for further functionalisation. The hydantoin framework itself is widely recognised as a pharmacophore core in a broad range of bioactive molecules, which is why methylated derivatives such as this one frequently become the starting point for compound library construction in medicinal chemistry and materials chemistry research.
The principal characteristics that lead researchers to select 1-Methylhydantoin are the high stability of its hydantoin ring under ordinary reaction conditions, combined with the presence of a nitrogen position and an alpha carbon that remain reactive toward alkylation as well as aldol condensation with aromatic aldehydes. The asymmetric substitution pattern — one nitrogen already methylated while the other still carries a hydrogen — gives chemists clear regioselective control when installing new substituents onto the ring. This balance between a robust core and well-defined reactive positions makes the material predictable to work with across multi-step synthetic sequences.
In Indonesian laboratories, 1-Methylhydantoin is typically handled in university organic synthesis groups, government research institutes, and industrial R&D units engaged in the preparation of heterocyclic derivatives. Its crystalline solid form makes it convenient to weigh accurately on an analytical balance and to dispense in the small quantities characteristic of exploratory synthesis and screening work, where reproducible measurement of the starting material directly determines the reliability of subsequent reaction steps.
- Heterocyclic building block synthesis — the intact imidazolidine-2,4-dione ring supplies a ready-made five-membered scaffold, sparing researchers the effort of constructing the heterocyclic core from acyclic precursors.
- Medicinal chemistry library construction — because the hydantoin motif is an established pharmacophore core in bioactive molecules, this methylated derivative serves as a practical starting point for generating analogue series.
- Regioselective N-alkylation studies — with one nitrogen already methylated and the other still bearing hydrogen, the asymmetric substitution pattern gives unambiguous control over where new substituents are installed.
- Aldol condensation with aromatic aldehydes — the alpha carbon of the hydantoin ring remains reactive toward condensation chemistry, allowing arylidene derivatives to be prepared for further structural elaboration.
- Materials chemistry research — the stable hydantoin framework functions as a rigid heterocyclic subunit when researchers build larger functional molecules requiring a predictable, reaction-tolerant core.
| Brand | TCI (Tokyo Chemical Industry) |
|---|---|
| CAS number | 616-04-6 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Heterocyclic Building Blocks |
| Pack sizes | — |
| Physical form | crystalline solid |
| Storage | store in a closed container under the conditions stated on the manufacturer's label |
- Product code: M1027
Store 1-Methylhydantoin in its original tightly closed container in a cool, dry, and well-ventilated area, away from moisture and from direct sunlight. Amber or opaque glass bottles with chemically resistant closures are suitable for storage and for any repackaging into working quantities. Handle the crystalline solid inside a fume hood or in an adequately ventilated workspace to avoid inhaling dust generated during weighing and transfer, and wear standard laboratory personal protective equipment including safety goggles, chemically resistant gloves, and a laboratory coat. Use clean, dry spatulas and weighing vessels to prevent contamination of the bulk material, and reseal the container immediately after use. Follow the manufacturer's safety data sheet for detailed handling instructions, incompatibility information, and disposal procedures applicable in your laboratory.
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