TCI M1983 1-Methyl-1,2-epoxycyclohexane is a cyclic epoxide built on a cyclohexane skeleton, carrying a methyl group on one of the carbon atoms of the oxirane ring. In organic chemistry laboratories, epoxides are among the most useful functional groups available, because their three-membered ring holds considerable strain and is therefore opened very readily by a wide range of nucleophiles. This particular compound is of special interest because it belongs to the class of more highly substituted epoxides, which makes it an important substrate for studying how substitution patterns influence the direction of nucleophilic attack and the final outcome of ring-opening reactions.
The characteristics that make this material a preferred choice are its informative regioselective and stereochemical behaviour. Under basic or neutral conditions, nucleophiles tend to attack the less hindered carbon, whereas under acidic conditions the attack is directed more towards the more substituted carbon because of the stabilisation of partial positive charge. This difference makes the compound a classic teaching example in discussions of reaction mechanism, and at the same time an excellent test substrate for evaluating new catalysts. The cyclohexane framework additionally introduces ring stereochemistry, since opening of the epoxide generates products whose configuration reflects the pathway taken.
In Indonesian laboratories, this building block is typically used in academic and institutional organic chemistry settings where mechanism-focused work is carried out. It supports university teaching laboratories demonstrating epoxide chemistry, research groups developing and benchmarking catalytic systems, and synthetic programmes that need a substituted cyclic epoxide as a starting fragment. It is handled in standard synthetic glassware on a research scale, within the Chemistry building blocks portfolio supplied by AMI Scientific.
- Epoxide ring-opening studies: the strained three-membered ring is readily attacked by a broad range of nucleophiles, giving reliable and reproducible reactions for systematic investigation of nucleophilic substitution behaviour.
- Regioselectivity teaching experiments: the contrast between attack at the less hindered carbon under basic conditions and the more substituted carbon under acidic conditions makes this a classic demonstration substrate.
- Catalyst evaluation and benchmarking: because its ring-opening outcome is sensitive to reaction conditions, the compound works well as a test substrate for assessing the activity and selectivity of newly developed catalysts.
- Stereochemistry investigations: the cyclohexane framework introduces ring stereochemistry, so epoxide opening produces products whose configuration reveals the stereochemical course of the reaction pathway.
- Non-heterocyclic building block in synthesis: as a substituted cyclic epoxide, it serves as a reactive fragment that can be elaborated into more complex structures in multi-step organic synthesis work.
| Brand | TCI |
|---|---|
| CAS number | 1713-33-3 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Non-Heterocyclic Building Blocks |
| Pack sizes | available in the standard research-scale pack sizes listed for this catalogue item; please refer to the product listing for the currently offered options. |
| Physical form | — |
| Storage | — |
- Chemical name: 1-Methyl-1,2-epoxycyclohexane
- Product code: M1983
Store the container tightly closed in a cool, dry and well-ventilated place, away from heat sources, open flames and direct sunlight, and keep it separated from strong acids, oxidising agents and other incompatible materials, since epoxides are reactive towards acidic and nucleophilic species. Keep the material in its original supplier container, or in a compatible tightly sealed glass bottle with a chemically resistant closure. Handle only inside a working fume hood, wearing safety goggles, a laboratory coat and suitable chemical-resistant gloves. Avoid inhalation of vapours and any contact with skin and eyes, close the container immediately after dispensing, and follow the manufacturer's safety data sheet together with your institution's chemical waste procedures for disposal.
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