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Description
TCI D4085, CAS 1132-95-2, is 1,1-Diisopropoxycyclohexane, a cyclohexanone ketal formed from cyclohexanone and two molecules of isopropanol. The compound belongs to the class of non-heterocyclic building blocks and functions primarily as a protecting-group transfer reagent and a water scavenger in organic reactions. Rather than becoming a permanent part of the target molecule, this type of compound more often serves as a synthetic auxiliary: it supplies a protected form of cyclohexanone that is ready to exchange groups with other alcohols or diols through transacetalization under mild acid catalysis in the laboratory.
The advantage that makes this reagent a preferred choice is its ability to form acetals or ketals without the need for cumbersome azeotropic heating with a Dean–Stark apparatus. When reacted with a target alcohol or diol, the group exchange releases isopropanol, which is readily evaporated, so the equilibrium is driven toward the desired product. Because it is supplied as a liquid, the reagent is conveniently transferred with a syringe or pipette and is easy to measure volumetrically. As a ketal, however, the compound is sensitive to moisture and acid, so strictly anhydrous conditions are essential for reliable results.
In Indonesian laboratories, this reagent is typically used in academic and industrial organic synthesis settings where protected carbonyl intermediates are prepared on a bench scale. It is handled in a fume hood using dry glassware, inert-atmosphere lines, and syringe transfer techniques common in university research groups, pharmaceutical development laboratories, and fine chemical R&D units. Its liquid form makes it practical for routine volumetric dispensing in small-scale reaction work.
Laboratory Applications
- Carbonyl protection chemistry: it delivers a ready-made cyclohexanone ketal that transfers the protecting group to a target substrate under mild acid catalysis without a separate condensation step.
- Transacetalization reactions: the isopropoxy groups exchange readily with other alcohols or diols, and the isopropanol released is easily evaporated to drive the equilibrium forward.
- Acetal and ketal formation without Dean–Stark: it removes the need for cumbersome azeotropic distillation setups, simplifying apparatus requirements for laboratories running frequent protection reactions.
- Water scavenging in organic reactions: as a ketal it consumes adventitious water in the reaction medium, helping maintain the anhydrous conditions that moisture-sensitive transformations require.
- Non-heterocyclic building block work: it serves as a synthetic auxiliary in multi-step routes where a protected cyclohexanone equivalent is needed rather than a permanent structural fragment.
Specifications
- Brand: TCI
- CAS number: 1132-95-2
- Chemical name: 1,1-Diisopropoxycyclohexane
- Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
- Physical form: liquid, suitable for syringe or pipette transfer and volumetric measurement
- Pack sizes: available in standard TCI research-scale packaging; please confirm the available pack size when ordering
- Storage note: keep under anhydrous conditions, protected from moisture and acid
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated area away from moisture and acidic materials, since the ketal function is sensitive to both. Original manufacturer bottles with tight-sealing caps, or septum-capped bottles for inert-atmosphere storage, are the most suitable containers. Handle the liquid inside a fume hood using dry glassware, and transfer it with a clean, dry syringe or pipette to avoid introducing water. Wear a laboratory coat, chemical-resistant gloves, and safety goggles. Keep containers closed when not in use, avoid contact with skin and eyes, and consult the manufacturer's safety data sheet before use and before disposal of residues.
