TCI M3133 Mitoxantrone, bearing CAS number 65271-80-9, is a synthetic anthracenedione compound supplied as a pharmaceutical research reagent for experimental use. Its molecule consists of a hydroxylated anthraquinone core carrying two aminoalkylamino side chains, a design that gives it a strong capacity to interact with nucleic acids. In research laboratories, this compound is widely used as a comparator tool in studies of anticancer drug mechanisms, cell biology research, and analytical method development. Its role is that of a reference compound whose behaviour has been extensively documented in the scientific literature.
The characteristics that make it a preferred choice among researchers are its ability to intercalate between DNA base pairs and to inhibit the action of topoisomerase II enzymes, two mechanisms that have long served as reference points in studies of DNA damage and cellular response. The extensive conjugated aromatic system also gives the compound its characteristic dark bluish colour and strong light-absorbing properties, so that it can be readily monitored by spectrophotometry. The protonatable amine side chains influence its solubility and its interactions with charged macromolecules, making the compound convenient to handle across a range of experimental conditions.
In Indonesian laboratories, this reagent is typically used within university research groups, pharmaceutical research institutions, and analytical laboratories that require a well-characterised reference compound for experimental work. It supports method development and validation activities, comparative studies of compound behaviour in biological systems, and teaching or training work at the postgraduate level. Because its properties are well documented, it provides a dependable point of comparison when laboratories establish or verify their own experimental procedures.
TCI brochures (PDF)
- Ubiquitin-Proteasome System (UPS) Research Reagents 2025-07-03 · p. 1
- Antimicrobials and Antitumor Agents for Research and Experimental Use 2025-04-24 · p. 16
- Pharmaceutical Ingredients for Research and Experimental Use 2026-03-09 · p. 17
- Reagents for Biological Research 2025-03-11 · p. 27
- DNA interaction studies: the compound intercalates between DNA base pairs, making it a well-documented model system for investigating how small molecules bind to and distort nucleic acid structures.
- Topoisomerase II research: because it inhibits topoisomerase II activity, it serves as a standard tool for probing enzyme function and the cellular consequences of disrupted DNA topology.
- Anticancer mechanism comparison studies: its extensively published behaviour allows researchers to use it as a benchmark compound when evaluating the action of newly investigated candidate molecules.
- Spectrophotometric method development: the extended conjugated aromatic system produces strong light absorption, so the compound is readily detected and quantified during analytical method design and validation.
- Cell biology and DNA damage response research: its established mechanisms of action make it a reliable experimental reference for studying cellular responses to nucleic acid damage.
| Brand | TCI |
|---|---|
| CAS number | 65271-80-9 |
| Molecular formula | — |
| Purity | — |
| Category | Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use) |
| Pack sizes | available in standard TCI research packaging; please confirm the required size when ordering |
| Physical form | solid with a characteristic dark bluish colour |
| Storage | store according to the conditions stated on the manufacturer's label and accompanying documentation |
Store the container tightly closed in a cool, dry place away from direct sunlight and sources of heat, following the storage conditions stated on the manufacturer's label. Keep the material in its original supplier container, or in a tightly sealed, chemically compatible amber or opaque container that protects the contents from light and moisture. Handle the compound only in a properly ventilated laboratory area, preferably within a fume hood, and always wear appropriate personal protective equipment including gloves, a laboratory coat, and eye protection. As with all pharmaceutical research reagents intended for experimental use, avoid the generation of dust, prevent direct contact with skin and eyes, and consult the safety data sheet before beginning any work. Dispose of residues and contaminated materials in accordance with applicable institutional and local laboratory waste regulations.
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