1-Nitro-3-(trifluoromethoxy)benzene TCI N0884

Chemical Identity

CAS No.: 2995-45-1
PubChem: CID 2777297·SID 125307684
Formula: C7H4F3NO3
Molecular weight: 207.11 g/mol
Purity: >95.0%(GC)
Reference databases: ECHA

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 1-nitro-3-(trifluoromethoxy)benzene
SMILES: C1=CC(=CC(=C1)OC(F)(F)F)[N+](=O)[O-]
InChIKey: QBWJNDOQIAARBT-UHFFFAOYSA-N

Rp 1.326.150,00

Sale Sold out

Shipping calculated at checkout.

Berat 5g 25g

Pembayaran hanya melalui request quotation dan dilakukan setelah tim kami menghubungi Anda. Mohon cantumkan nomor WhatsApp aktif untuk konfirmasi pesanan & pembuatan invoice. Estimasi pengiriman 2-4 minggu setelah pembayaran.

Dokumen Keamanan & Mutu

↓ Unduh SDS / MSDS (PDF resmi TCI)

CoA (Certificate of Analysis)

Spesifik per batch produksi — diterbitkan dan dikirim bersama barang sesuai nomor lot yang Anda terima.

Contoh CoA segera tersedia.

💬 Minta CoA via WhatsApp

View full details

1-Nitro-3-(trifluoromethoxy)benzene from TCI (product code N0884, CAS 2995-45-1) is a substituted aromatic compound. Its molecule has a nitro group and a trifluoromethoxy (OCF3) group positioned meta to each other on a benzene ring. It belongs to the fluorinated building blocks, a class of materials that matters a great deal in medicinal chemistry, agrochemistry and modern materials science. In the laboratory, its main role is as a precursor to 3-(trifluoromethoxy)aniline, which is made by reducing the nitro group. That aniline is then the starting point for building amides, ureas, sulfonamides and heterocycles that carry the OCF3 group.

Chemists value the trifluoromethoxy group because it is strongly lipophilic, strongly electron-withdrawing and metabolically stable. Together, these properties are often used to improve membrane permeability and to make drug candidates more resistant to metabolic breakdown. Putting an OCF3 group directly onto a molecule is usually difficult. For that reason, a starting material that already carries the group, like this one, makes synthetic work much easier. The nitro group also gives a simple, controllable route for further transformation, so researchers can reach the target amine and its derivatives in fewer and more predictable steps than they would by adding the fluorinated group late in a synthesis.

In Indonesia, medicinal chemistry and agrochemical research keep growing at universities and research institutions. Laboratories working on new bioactive molecules, structure–activity relationship studies, or crop-protection candidates can use this compound as a dependable entry point to OCF3-substituted aromatic scaffolds. It also suits academic synthetic organic chemistry groups that teach or study nitro-group reduction and aniline chemistry. AMI Scientific supplies this TCI reagent to research, teaching and industrial development laboratories that need a well-defined fluorinated building block.

TCI brochures (PDF)

Fluorination Reagents, Fluorinated Building Blocks 2026-03-18 · p. 44

Related TCI products

Synthesis of 3-(trifluoromethoxy)aniline: reducing the nitro group gives the corresponding aniline directly, which makes this compound a simple and controllable precursor for that key fluorinated intermediate.
Construction of amide and urea derivatives: the aniline made from this compound can be coupled to form amides and ureas that keep the lipophilic, metabolically stable OCF3 group in the final structure.
Preparation of sulfonamides for medicinal chemistry: because the trifluoromethoxy group is already in place, researchers can make OCF3-bearing sulfonamides without the difficult step of installing the group directly.
Heterocycle synthesis for drug discovery: the derived aniline is a useful starting point for building heterocyclic systems that carry the OCF3 group, supporting work on membrane permeability and metabolic resistance.
Agrochemical research and development: fluorinated building blocks are central to modern agrochemistry, and this compound gives a practical route to OCF3-substituted aromatic candidates for crop-protection studies.

Brand	TCI (product code N0884)
CAS number	2995-45-1
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Fluorinated Building Blocks
Pack sizes	see the available options on the product listing
Physical form	see the TCI certificate of analysis or safety data sheet
Storage	follow the storage conditions on the TCI label and safety data sheet

Keep this compound in its original, tightly closed container. Store it in a cool, dry, well-ventilated place away from heat, ignition sources, strong reducing agents and incompatible materials. Always check the TCI label and safety data sheet for specific storage temperature requirements. As an aromatic nitro compound, it should be handled only by trained staff in a fume hood, wearing suitable gloves, safety glasses and a laboratory coat. Do not inhale vapours or dust, and avoid contact with skin and eyes. Label secondary containers clearly, and dispose of residues and contaminated materials according to institutional and local regulations for halogenated organic chemical waste.

—