6-Oxaspiro[2.5]octan-1-amine Hydrochloride TCI O0678

Chemical Identity

CAS No.: 1779133-13-9
Purity: >95.0%(qNMR)

Rp 8.453.550,00

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6-Oxaspiro[2.5]octan-1-amine Hydrochloride is the hydrochloride salt of a spirocyclic primary amine. Its structure joins a cyclopropane ring that carries the amine group to a tetrahydropyran ring through a single spiro carbon atom. The molecule can therefore be seen as a cyclopropylamine substituted with an oxacyclic framework. In medicinal chemistry laboratories, it serves as a heterocyclic building block for adding a rigid, three-dimensional primary amine group to target molecules during the synthesis of new compounds and analog series.

Chemists choose this material because it combines two structural motifs that both matter in drug design. The cyclopropane ring adds rigidity and a distinctive molecular shape, while the tetrahydropyran ring adds polarity and can help improve solubility. The primary amine is a very versatile handle that takes part in amide, urea and sulfonamide formation, as well as reductive amination. The hydrochloride salt form makes the compound easier to store and weigh accurately, and the free amine can be released with a base during the reaction.

In Indonesia, building blocks like this one are relevant to medicinal chemistry researchers at universities and research institutions who want to make analogs with better three-dimensional character and physicochemical properties. Typical users include synthetic organic chemistry groups, pharmaceutical science faculties running structure–activity relationship studies, and graduate students preparing compound libraries for biological screening. Because the material is used in small quantities for exploratory synthesis, a reliable supply of TCI research-grade reagents through AMI Scientific helps keep laboratory projects on schedule.

TCI brochures (PDF)

Building Blocks for Medicinal Chemistry 2025-05-12 · p. 1

Related TCI products

Amide coupling: the primary amine reacts readily with activated carboxylic acids, so it is a simple way to attach the rigid spirocyclic oxacyclic fragment to scaffolds of interest.
Urea and carbamate synthesis: the amine reacts with isocyanates or activated carbonyl reagents to give ureas, which lets chemists study how a three-dimensional amine substituent changes binding and properties.
Sulfonamide formation: reaction with sulfonyl chlorides gives sulfonamides that carry the cyclopropane–tetrahydropyran motif, which is useful for widening structural variety in medicinal chemistry series.
Reductive amination: the primary amine condenses with aldehydes or ketones and the product is then reduced, giving secondary amines that keep the spirocyclic framework's rigidity and polarity.
Structure–activity relationship studies: the compound combines cyclopropane rigidity with tetrahydropyran polarity, so it suits analog design aimed at better shape, solubility and overall drug-like properties.

Brand	TCI (product code O0678)
CAS number	1779133-13-9
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Heterocyclic Building Blocks
Pack sizes	Available in TCI standard pack sizes; please confirm current options with AMI Scientific
Physical form	—
Storage	Follow the storage conditions on the TCI label and Safety Data Sheet

Form: Hydrochloride salt of a spirocyclic primary amine; check the TCI product documentation for physical appearance

Store this compound in its original, tightly closed container, following the conditions stated on the TCI label and Safety Data Sheet. Keep it in a cool, dry, well-ventilated area away from moisture, strong bases and oxidizing agents. If you transfer portions, use clean, dry, chemically compatible glass or suitable plastic containers that are clearly labeled. Handle the material in a fume hood or well-ventilated area, and wear suitable gloves, safety glasses and a laboratory coat. Avoid breathing dust and avoid contact with skin and eyes. Reseal the container right after use to protect the contents from humidity. Dispose of waste according to local regulations and your institution's chemical safety procedures.

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