4-Formylbenzonitrile (CAS 105-07-7) from TCI is a bifunctional aromatic building block bearing an aldehyde and a nitrile group in the para position. The two electron-withdrawing groups create an electron-poor ring, enhancing carbonyl reactivity toward nucleophiles in Schiff base formation, Knoevenagel condensation, and Wittig-type olefination. Its nitrile group offers orthogonal transformations into carboxylic acids, primary amines, amidines, or tetrazole rings, making stepwise synthetic design straightforward. AMI Scientific offers this reagent in 5 g and 25 g packs for exploratory and routine laboratory synthesis.
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- J. Intelli (2024). Synthesis of 4-(2,2-Difluorovinyl)benzonitrile through a Wittig-type Olefination of 4-Formylbenzonitrile. Organic Syntheses doi:10.15227/orgsyn.101.0542
- Liu et al. (2017). Direct Access to Isoindolin‐1‐one Scaffolds by Copper‐Catalyzed Divergent Cyclizations of 2‐Formylbenzonitrile and Diaryliodonium Salts. Advanced Synthesis & Catalysis doi:10.1002/adsc.201601403
- Britton et al. (2006). 2-Formylbenzonitrile. Acta Crystallographica Section C Crystal Structure Communications doi:10.1107/s0108270106013138
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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