TCI C0429 3-Formylbenzonitrile (CAS 24964-64-5) is a bifunctional aromatic building block bearing both an aldehyde and a nitrile group in the meta position. The aldehyde readily undergoes condensation, reductive amination, and olefination reactions, allowing rapid extension of the carbon framework. The nitrile group can later be converted into carboxylic acids, amines, amidines, or tetrazoles, making the compound valuable in pharmaceutical and ligand synthesis. Store the solid in a cool, dry, and dark place, and weigh it in a fume hood with standard protective equipment.
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- J. Intelli (2024). Synthesis of 4-(2,2-Difluorovinyl)benzonitrile through a Wittig-type Olefination of 4-Formylbenzonitrile. Organic Syntheses doi:10.15227/orgsyn.101.0542
- Liu et al. (2017). Direct Access to Isoindolin‐1‐one Scaffolds by Copper‐Catalyzed Divergent Cyclizations of 2‐Formylbenzonitrile and Diaryliodonium Salts. Advanced Synthesis & Catalysis doi:10.1002/adsc.201601403
- Britton et al. (2006). 2-Formylbenzonitrile. Acta Crystallographica Section C Crystal Structure Communications doi:10.1107/s0108270106013138
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