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TCI

CAS 13511-38-1

3-Chloropivalic Acid TCI C1554

3-Chloropivalic Acid TCI C1554
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TCI C1554 3-Chloropivalic acid is a branched aliphatic carboxylic acid featuring a quaternary neopentyl center together with a beta-positioned chlorine atom. The sterically demanding gem-dimethyl motif is widely used to introduce conformational rigidity and to reduce oxidative metabolism in candidate molecules. Its beta-chloro substituent enables intramolecular cyclization toward oxetanes and lactones, while the carboxyl group can be converted into esters, amides, or reduced derivatives. AMI Scientific supplies this TCI building block in a 25 g pack for organic synthesis, medicinal chemistry, and agrochemical research laboratories.

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  • Aksnes et al. (1999). High-field multinuclear magnetic resonance studies of molecular motions in the liquid and solid phases of 3-chloropivalic acid. Journal of Molecular Structure doi:10.1016/s0022-2860(98)00757-1
  • Buhrmester et al. (2000). Low temperature structure and dynamics of β-chloropivalic acid. Acta Crystallographica Section A Foundations of Crystallography doi:10.1107/s0108767300027094
  • Chuchani et al. (2001). A Combined Experimental and Theoretical Study of the Homogeneous, Unimolecular Decomposition Kinetics of 3-Chloropivalic Acid in the Gas Phase. The Journal of Physical Chemistry A doi:10.1021/jp003560t

References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.