• 4-Chloro-2-methoxybenzoic Acid (CAS 57479-70-6) - TCI C2076 - AMI Scientific
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TCI

CAS 57479-70-6

4-Chloro-2-methoxybenzoic Acid TCI C2076

4-Chloro-2-methoxybenzoic Acid TCI C2076
Rp 1.151.850,00
Rp 1.151.850,00
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TCI C2076 is 4-Chloro-2-methoxybenzoic Acid, a substituted benzoic acid carrying a chlorine atom at the para position relative to the carboxyl group and a methoxy group at the ortho position. The compound belongs to the family of highly versatile non-heterocyclic building blocks, because it presents three structural elements at once within a single simple benzene ring: an acid group ready to be activated, an electron-donating methoxy group, and a halogen that can serve as a coupling point. In the laboratory, this material is widely used as a starting material for constructing amides, esters, fused heterocycles, and a variety of other synthetic intermediates.

The property that makes this building block attractive is a substitution pattern that produces distinctive electronic and steric behaviour. The methoxy group at the ortho position influences the acidity and the reactivity of the neighbouring carboxyl group while also directing subsequent electrophilic substitution reactions, whereas the chlorine atom at the para position inductively lowers the electron density of the ring and provides a handle for cross-coupling reactions or nucleophilic aromatic substitution under appropriate conditions. This combination gives researchers good regiochemical control when designing target molecules, since each functional group can be addressed in a planned sequence rather than competing with the others.

In Indonesian laboratories, this reagent is typically encountered in university and institutional organic synthesis groups, in medicinal chemistry and pharmaceutical research programmes, and in analytical or method-development work where a well-defined substituted benzoic acid is required as a reference structure or intermediate. It is generally ordered in small research quantities for bench-scale route exploration, then carried forward into amidation, esterification, or coupling steps as the synthetic plan develops.

  • Amide synthesis: the carboxyl group can be activated and coupled with amines, making this acid a direct entry point to substituted benzamide scaffolds used in medicinal chemistry route development.
  • Ester preparation: esterification of the carboxyl group provides protected or modified derivatives, allowing chemists to mask acidity while further functionalising the aromatic ring in later steps.
  • Fused heterocycle construction: the combination of an acid group and an ortho methoxy substituent supports cyclisation strategies that build condensed heterocyclic systems from a simple benzene starting point.
  • Cross-coupling chemistry: the para chlorine atom acts as a coupling handle for transition-metal-catalysed carbon-carbon and carbon-heteroatom bond formation, extending the molecular framework in a controlled direction.
  • Nucleophilic aromatic substitution: under suitable conditions the electron-poor ring created by the inductive effect of chlorine allows displacement chemistry, giving an alternative route to further substituted benzoic acid derivatives.

Brand TCI (Tokyo Chemical Industry)
CAS number 57479-70-6
Molecular formula —
Purity —
Category Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes supplied in standard TCI research pack sizes; please confirm the currently listed packaging option when ordering
Physical form —
Storage store according to the conditions stated on the manufacturer label and Safety Data Sheet
  • Chemical name: 4-Chloro-2-methoxybenzoic Acid

Store the container tightly closed in a cool, dry, well-ventilated area away from direct sunlight, moisture, and incompatible materials, following the conditions printed on the manufacturer label and Safety Data Sheet. Keep the substance in its original supplier packaging or in a clean, chemically compatible and clearly labelled container. Handle in a fume hood using standard personal protective equipment, including safety glasses, gloves, and a laboratory coat, and avoid generating dust or inhaling vapours. As an organic acid it should be kept separate from strong bases and strong oxidising agents. Always consult the Safety Data Sheet before first use, and dispose of residues and contaminated materials through the institution's approved chemical waste procedures.

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