2-Chlorobenzohydrazide TCI C2116

Rp 1.417.500,00

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Berat 5g 25g

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Description

TCI C2116 2-Chlorobenzohydrazide is an aromatic acyl hydrazide built from a benzene ring bearing a chlorine substituent at the ortho position, combined with a hydrazide group (–CONHNH₂) that serves as the centre of its reactivity. In synthetic laboratories, this material occupies an important position as a bridge between simple carbonyl chemistry and nitrogen heterocyclic chemistry. Researchers use it to convert aldehydes and ketones into hydrazones, or to construct the nitrogen-rich five-membered rings that form the backbone of many active compound candidates. Its role as a building block makes synthetic routes considerably more concise and reproducible.

The property that leads chemists to select this compound lies in the binucleophilic character of the hydrazide group. Its terminal nitrogen readily attacks carbonyl groups to form hydrazones, while the combination of the nitrogen atoms and the amide oxygen permits cyclisation into 1,3,4-oxadiazoles, 1,2,4-triazoles, and thiosemicarbazide derivatives using relatively simple reagents. The chlorine atom at the ortho position contributes a distinctive electronic and steric influence, frequently affecting the conformation of the final product as well as the strength of its binding to biological targets. Hydrazones and their derived products are likewise readily accessible from this single starting material.

In Indonesian laboratories, this building block is typically encountered in academic and institutional research settings where medicinal chemistry, organic synthesis, and heterocyclic compound development are pursued. University research groups and postgraduate students working on nitrogen heterocycle programmes rely on defined building blocks of this type to shorten multi-step routes. It is generally ordered in research-scale quantities, handled within standard synthetic organic chemistry workflows, and stored alongside other reactive intermediates in a controlled chemical store.

Laboratory Applications

Hydrazone synthesis: the terminal nitrogen condenses directly with aldehydes and ketones, giving researchers a straightforward and reproducible route to structurally varied hydrazone products.
1,3,4-Oxadiazole ring construction: the combined nitrogen and amide oxygen functionality allows cyclisation into this five-membered heterocycle using comparatively simple reagents and conditions.
1,2,4-Triazole preparation: the binucleophilic hydrazide moiety supports ring closure to nitrogen-rich triazole scaffolds that underpin many biologically active compound candidates.
Thiosemicarbazide derivative formation: the reactive hydrazide centre enables conversion into thiosemicarbazide analogues, extending the range of nitrogen-containing structures accessible from one intermediate.
Medicinal chemistry building block work: the ortho-chlorine substituent imparts distinctive electronic and steric effects that influence product conformation and binding strength at biological targets.

Specifications

Brand: TCI
CAS number: 5814-05-1
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Chemical class: aromatic acyl hydrazide bearing an ortho-chlorinated benzene ring and a –CONHNH₂ group
Pack sizes: research-scale packaging as supplied by the manufacturer; please confirm the available option when ordering
Storage: keep in the tightly closed original container in a cool, dry, well-ventilated chemical store

Handling and Storage

Store the material in its tightly closed original container in a cool, dry and well-ventilated chemical store, away from direct sunlight, heat sources, moisture, and incompatible substances such as strong oxidising agents and strong acids. Glass or the manufacturer's supplied packaging is suitable for containment, and containers should be resealed promptly after each use to limit exposure to atmospheric moisture. Handle in a fume hood while wearing safety goggles, chemical-resistant gloves, and a laboratory coat. Avoid the generation of dust, skin and eye contact, and inhalation of vapour. Always consult the manufacturer's safety data sheet before use and dispose of residues through the approved chemical waste route.