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Description
Ancitabine Hydrochloride (TCI C2207), also known as cyclocytidine hydrochloride, is a pyrimidine nucleoside derivative supplied as a hydrochloride salt, featuring an anhydro bridge that links the cytosine base to the arabinofuranose sugar moiety. This cyclic structure is what distinguishes it from ordinary nucleosides and makes it an interesting subject of study in medicinal chemistry laboratories. The compound is used as a research material and reference substance in studies of nucleoside antimetabolites, particularly those relating to the arabinonucleoside group, as well as a synthetic intermediate on the route toward other modified cytidine derivatives at laboratory scale.
The properties that make this material a preferred choice are the combination of its hydrochloride salt form and its reactive anhydro framework. The salt form generally offers more practical handling of the solid and better solubility in aqueous media compared with the free base, which simplifies the preparation of stock solutions for in vitro assays. Meanwhile, the 2,2'-anhydro bridge can be opened by nucleophiles, thereby opening synthetic routes toward nucleosides with the arabino configuration or with particular 2'-substituents. The reagent quality supplied by TCI helps maintain consistency of results across repeated experiments.
In Indonesian laboratories, this reagent is typically encountered in university research groups, pharmaceutical chemistry departments, and institutional research centres working on nucleoside chemistry. It is generally ordered in small research quantities for synthetic route development, for use as a reference material in analytical comparison work, and for preliminary in vitro studies. Because it is a specialised biochemical rather than a routine bulk chemical, it is usually purchased per project according to the requirements of the experimental plan rather than kept as a standing stock item.
Laboratory Applications
Nucleoside antimetabolite research: the compound serves as a study material for investigating the behaviour of arabinonucleoside-type antimetabolites, allowing researchers to examine how the cyclic framework influences activity relative to conventional nucleosides.
Synthetic intermediate work: the reactive 2,2'-anhydro bridge can be opened by nucleophiles, making this material a practical starting point for laboratory-scale preparation of modified cytidine derivatives and arabino-configured nucleosides.
Reference material in analytical comparison: the defined identity of this catalogue compound makes it suitable for use as a comparison standard when characterising related nucleoside structures by chromatographic or spectroscopic methods.
In vitro assay preparation: the hydrochloride salt form provides better solubility in aqueous media than the free base, which simplifies the preparation of stock solutions used in cell-based and biochemical assay work.
Medicinal chemistry teaching and methodology development: the distinctive anhydro-bridged structure makes it a useful example compound for advanced coursework and for developing and validating handling procedures for sensitive nucleoside derivatives.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS Number: 10212-25-6
Catalogue Number: C2207
Category: Life Science > Biochemicals and Reagents > Nucleosides, Nucleotides, Oligonucleotides
Chemical Form: hydrochloride salt of a pyrimidine nucleoside derivative (solid)
Pack Sizes: available in laboratory research quantities; please refer to the current catalogue listing for the sizes offered
Storage: refer to the manufacturer's label and safety data sheet for the recommended storage conditions
Handling and Storage
Store this reagent in accordance with the conditions stated on the manufacturer's label and in the accompanying safety data sheet. As a general practice for nucleoside derivatives, keep the container tightly closed in a cool, dry place, protected from light and moisture, and use containers that are chemically compatible and well sealed to prevent moisture uptake by the solid. Handle the material in a well-ventilated area or fume hood, wearing gloves, safety glasses, and a laboratory coat, and avoid generating dust when weighing. Allow the container to reach room temperature before opening to reduce condensation. Label all prepared solutions clearly with the compound identity and preparation date, and dispose of residues and contaminated consumables through the laboratory's established chemical waste procedures.
