4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline TCI C2774

Chemical Identity

CAS No.: 183322-18-1
PubChem: CID 11289942·SID 468591051
Formula: C14H17ClN2O4
Molecular weight: 312.75 g/mol
Purity: >98.0%(HPLC)(N)
Reference databases: ECHA

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
SMILES: COCCOC1=C(C=C2C(=C1)C(=NC=N2)Cl)OCCOC
InChIKey: ZPJLDMNVDPGZIU-UHFFFAOYSA-N
MDL: MDL09751265

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4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline is a heterocyclic quinazoline compound that serves as a building block, or starting scaffold, in organic synthesis within the laboratory. The molecule carries a chlorine atom at position 4 and two 2-methoxyethoxy chains at positions 6 and 7, a substitution pattern that makes it both reactive and highly functional for a wide range of chemical transformations. In everyday laboratory practice, this compound is commonly employed as an intermediate in the design of drug-like molecules, particularly quinazoline derivatives that are widely developed as enzyme inhibitors and as active pharmaceutical candidates. Researchers in medicinal chemistry and synthetic organic chemistry use this building block to construct increasingly complex molecular frameworks in a stepwise, controlled manner.

The main advantage of this compound lies in the reactivity of its chlorine atom, which can be readily substituted by a variety of nucleophiles, enabling flexible structural modification at a late stage of synthesis. This makes the molecule a versatile handle for introducing diverse substituents and for fine-tuning the properties of target compounds. At the same time, the relatively polar 2-methoxyethoxy groups improve the compound's solubility in common organic solvents and can influence the physicochemical behavior of the final products, such as lipophilicity and bioavailability. As a TCI product, it benefits from the brand's recognized quality standards and consistency, giving laboratories confidence in batch-to-batch reproducibility for demanding synthetic procedures.

In Indonesian laboratories, this building block is typically used in medicinal chemistry research programs and in the preparation of quinazoline-based intermediates for further elaboration. Academic and industrial researchers incorporate it into multi-step synthetic routes aimed at generating libraries of analogs for structure-activity relationship studies. Its predictable reactivity and compatibility with standard laboratory techniques make it a routine choice for teams working on enzyme inhibitor discovery and on the development of new heterocyclic compounds. The compound fits naturally into the workflow of synthetic organic chemistry groups that value reliable starting materials for building complex molecular architectures in a controlled manner.

Related TCI products

Medicinal chemistry intermediate synthesis: This compound serves as a central scaffold for assembling quinazoline-based drug candidates, allowing researchers to build enzyme inhibitor structures step by step with reliable, reproducible chemistry.
Nucleophilic substitution reactions: The chlorine atom at position 4 is readily displaced by amines, alcohols, and other nucleophiles, making this building block ideal for introducing diverse functional groups during analog preparation.
Structure-activity relationship studies: The two polar 2-methoxyethoxy chains and the reactive chlorine position allow systematic modification of the molecule, enabling laboratories to screen how each structural change affects biological activity.
Multi-step organic synthesis routes: Its predictable reactivity and good solubility in common organic solvents make this compound a dependable starting material for constructing more complex heterocyclic frameworks in extended synthetic pathways.
Building block for heterocyclic libraries: As a heterocyclic quinazoline derivative, it is well suited for generating small collections of related compounds that support medicinal chemists exploring new lead structures.

Brand	TCI
CAS number	183322-18-1
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Heterocyclic Building Blocks
Pack sizes	available in standard laboratory quantities; please confirm current size options with the supplier
Physical form	—
Storage	—

Product reference: C2774
Chemical name: 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

Store this compound in a tightly sealed container in a cool, dry, and well-ventilated area, protected from moisture and direct sunlight, as is standard practice for reactive organic intermediates. Keep the container closed when not in use and avoid exposure to humid conditions that could promote hydrolysis of the reactive chloro position. Use suitable laboratory containers, preferably the original packaging or chemically compatible glassware, and label all transferred material clearly. When handling, wear appropriate personal protective equipment, including gloves and safety glasses, and work in a fume hood or adequately ventilated area to minimize inhalation of dust. Avoid contact with skin and eyes, and wash hands thoroughly after handling. Follow general laboratory hygiene practices and consult the safety data sheet provided by the supplier for detailed hazard information before use.

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