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Description
TCI C3114 5-Chloro-2-fluorobenzaldehyde is a halogenated benzaldehyde that carries a chlorine atom at the five position and a fluorine atom at the two position relative to the aldehyde group. The compound belongs to the fluorinated building blocks family, a class of fluorine-bearing starting materials in high demand for the synthesis of pharmaceuticals, pesticides, and functional materials. In the laboratory its role is to supply an aromatic scaffold carrying three distinct reactive points at once, allowing researchers to construct complex molecules through a controlled sequence of reactions.
The characteristic that makes this material attractive is the orthogonal reactivity between its functional groups. The aldehyde group is ready to undergo reduction, oxidation, condensation, and reductive amination to form carbon–nitrogen and carbon–carbon bonds. The fluorine atom, sitting ortho to the aldehyde, is strongly activated toward nucleophilic aromatic substitution and is therefore readily displaced by nucleophiles such as phenols, thiols, or amines, providing a shortcut to fused heterocyclic systems. Meanwhile the far less reactive chlorine atom survives untouched, remaining available as a handle for palladium-catalysed coupling reactions at a later stage.
In Indonesian laboratories, this building block is typically encountered in university research groups, pharmaceutical research and development units, and agrochemical laboratories working on multi-step synthesis routes. It is handled on the bench in fume hoods during small-scale reaction work, where the ability to differentiate the aldehyde, the fluorine, and the chlorine across separate steps allows synthetic chemists to plan efficient routes toward target molecules without additional protecting-group manipulations.
Laboratory Applications
- Pharmaceutical intermediate synthesis: the three differentiated reactive positions let medicinal chemists elaborate a single scaffold step by step into drug-like target molecules through controlled reaction sequences.
- Fused heterocycle construction: the ortho-fluorine is activated toward nucleophilic aromatic substitution by phenols, thiols, or amines, giving a direct shortcut into fused heterocyclic ring systems.
- Palladium-catalysed cross-coupling chemistry: the comparatively unreactive chlorine atom is retained through earlier transformations and then used as the coupling handle in a later stage.
- Agrochemical and pesticide research: as a fluorinated building block it supplies the fluorine-bearing aromatic core that pesticide discovery programmes require for their candidate structures.
- Functional materials preparation: the aldehyde undergoes reduction, oxidation, condensation, and reductive amination, forming the carbon–nitrogen and carbon–carbon bonds needed to assemble functional material precursors.
Specifications
- Brand: TCI, supplied under catalogue code C3114
- CAS number: 96515-79-6
- Chemical name: 5-Chloro-2-fluorobenzaldehyde
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Pack sizes: available in the standard TCI catalogue pack sizes for this catalogue code
- Storage: store according to the conditions stated on the product label and safety data sheet
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated area away from direct sunlight, heat sources, and incompatible materials, following the storage conditions stated on the manufacturer label and safety data sheet. Keep the material in its original supplier container, or in a chemically compatible tightly sealed glass container, and label it clearly. Handle inside a working fume hood while wearing safety glasses, chemical-resistant gloves, and a laboratory coat, since aldehydes and halogenated aromatics can irritate the eyes, skin, and respiratory tract. Avoid the generation of vapours, keep the container closed when not in use, and consult the safety data sheet before first handling and before disposal.
