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Description
TCI C2127 3-Chloro-2-fluorobenzaldehyde is a doubly halogenated benzaldehyde supplied as a fluorinated building block. The aldehyde group is one of the most versatile functional groups in organic chemistry, since it can be converted into alcohols, carboxylic acids, amines, alkenes, and a wide range of heterocyclic rings. When that group already carries fluorine and chlorine atoms at defined positions, researchers gain a valuable shortcut: the desired halogenation pattern is installed from the outset, so synthetic sequences become shorter and their outcomes easier to predict.
The property that makes this compound a preferred choice is its high but controllable carbonyl reactivity. The fluorine atom in the ortho position increases the electrophilic character of the carbonyl carbon, so nucleophilic addition, condensation, and reductive amination reactions generally proceed smoothly. That same fluorine can potentially be displaced through nucleophilic aromatic substitution under suitable conditions, opening an additional synthetic branch. The chlorine atom, meanwhile, remains relatively inert under those conditions and is preserved as a cross-coupling handle for later stages of a synthetic route.
In Indonesian laboratories, this building block is typically used in university and institutional research groups working on organic synthesis, medicinal chemistry, and materials chemistry, where aromatic fluorine is a recurring design element. It is normally ordered in small research quantities for method development, scale-down route exploration, and the preparation of intermediates that are subsequently characterised in-house, rather than for routine bulk production work.
Laboratory Applications
- Medicinal chemistry intermediate synthesis: the pre-installed fluorine and chlorine pattern lets researchers build candidate scaffolds without adding separate, often difficult, halogenation steps to the route.
- Heterocycle construction: the reactive aldehyde group condenses readily with amines, hydrazines, and other bifunctional partners to form halogen-substituted ring systems in a single operation.
- Cross-coupling route development: the relatively inert chlorine atom survives early transformations and remains available as a coupling handle for later carbon–carbon bond formation.
- Nucleophilic aromatic substitution studies: the ortho fluorine can be displaced under suitable conditions, making the compound useful for exploring alternative substitution branches from one common starting material.
- Reductive amination and condensation chemistry: the electrophilically activated carbonyl carbon reacts smoothly with nucleophiles, giving reliable access to substituted benzylamines and related derivatives.
Specifications
- Brand: TCI
- CAS number: 85070-48-0
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Product code: C2127
- Pack sizes: available in standard TCI research-scale pack sizes; please confirm the required size when ordering
- Storage: store in a cool, dry place in a tightly closed container, away from light and moisture
Handling and Storage
Store the compound in its original tightly closed container in a cool, dry, and well-ventilated area, away from direct sunlight, heat sources, and moisture. Aromatic aldehydes are generally sensitive to air and can oxidise over time, so keep the container sealed and minimise the time it stays open on the bench. Handle the material inside a fume hood using nitrile gloves, safety glasses, and a laboratory coat, and avoid contact with skin, eyes, and clothing. Keep it separated from strong oxidising agents and strong bases. Always consult the manufacturer's safety data sheet before use, and dispose of residues and contaminated materials through the laboratory's chemical waste procedures.
