• N,N-Dimethylformamide Dimethyl Acetal [for Esterification] (CAS 4637-24-5) - TCI D2071 - AMI Scientific
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TCI

CAS 4637-24-5

N,N-Dimethylformamide Dimethyl Acetal [for Esterification] TCI D2071

N,N-Dimethylformamide Dimethyl Acetal [for Esterification] TCI D2071
Rp 2.067.450,00
Rp 2.067.450,00
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TCI D2071 N,N-Dimethylformamide Dimethyl Acetal, commonly abbreviated as DMF-DMA, is a versatile liquid reagent prepared specifically for esterification work. In the laboratory it acts as a mild methylating agent that rapidly converts carboxylic acids into their methyl esters without requiring strong mineral acids or hazardous diazomethane. This role is particularly important during sample preparation prior to gas chromatographic analysis, because many organic acids are insufficiently volatile and are difficult to separate cleanly until they have been converted into their more readily analysed ester derivatives.

The properties that make this reagent a preferred choice are its selective reactivity and its comparatively gentle reaction conditions. The aminal acetal group in its structure readily releases methanol and forms a reactive intermediate species, so esterification can proceed under moderate heating with by-products that are easily evaporated away. DMF-DMA is also well known as an enaminone-forming reagent and as a one-carbon source for heterocyclic synthesis, including pyrazoles, pyrimidines, and isoxazoles, so a single bottle can support several different kinds of work at once.

Because it is supplied in liquid form, the reagent is straightforward to measure and to add directly to a reaction mixture or to a derivatisation vial. In Indonesian laboratories this suits routine analytical service work, teaching and research laboratories in organic synthesis, and quality control settings where organic acid content is determined by gas chromatography. Its dual usefulness in both derivatisation and synthetic chemistry makes it a practical item to keep on hand where a single reagent inventory has to serve mixed workloads.

  • Methyl ester derivatisation for gas chromatography — converts poorly volatile organic acids into methyl esters that elute and separate far more cleanly, improving peak shape and quantitation in routine GC analysis.
  • Mild esterification of carboxylic acids — provides a route to methyl esters without strong mineral acid catalysts or hazardous diazomethane, which simplifies both the procedure and the safety controls required.
  • Enaminone formation in organic synthesis — reacts with activated methyl and methylene compounds to give enaminone intermediates that serve as flexible platforms for further ring-forming chemistry.
  • Heterocyclic building block chemistry — acts as a one-carbon source in the construction of pyrazoles, pyrimidines, and isoxazoles, supporting medicinal and materials-oriented synthetic programmes.
  • Teaching and research laboratory synthesis exercises — its moderate reaction conditions and easily evaporated by-products make reaction workup and product isolation more manageable for students and researchers alike.

Brand TCI
CAS number 4637-24-5
Molecular formula —
Purity —
Category Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes available in the standard TCI catalogue pack sizes for this item; please confirm the required size when ordering
Physical form liquid reagent, specified for esterification use
Storage keep tightly closed in a cool, dry, well-ventilated area away from moisture
  • Product code: D2071

Store the reagent in its original tightly closed container in a cool, dry, and well-ventilated chemical store, away from heat sources, ignition sources, and direct sunlight. Because the acetal group releases methanol on reaction, keep the container sealed against atmospheric moisture and reclose it promptly after each withdrawal; amber glass or the supplier's original glass packaging is appropriate. Handle and dispense in a fume hood, wearing safety glasses, chemically resistant gloves, and a laboratory coat. Use clean, dry glassware and dry syringes or pipettes when transferring, avoid contact with strong acids and oxidising agents, and consult the manufacturer's safety data sheet before first use and before disposal of residues.

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