• N,N-Dimethylformamide Dipropyl Acetal [for Esterification] (CAS 6006-65-1) - TCI D1301 - AMI Scientific
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TCI

CAS 6006-65-1

N,N-Dimethylformamide Dipropyl Acetal [for Esterification] TCI D1301

N,N-Dimethylformamide Dipropyl Acetal [for Esterification] TCI D1301
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TCI D1301 N,N-Dimethylformamide Dipropyl Acetal [for Esterification] is a member of the formamide acetal family carrying two propoxy groups, prepared specifically for esterification reactions in both synthesis and analytical laboratories. The reagent allows carboxylic acids to be converted directly into their propyl esters without a strong acid catalyst and without the need to add excess alcohol under prolonged reflux conditions. As a non-heterocyclic building block, it complements the dimethyl and diethyl variants within the same family of reagents, giving researchers a choice of ester alkyl group according to the demands of a particular analysis or synthetic target.

The distinguishing feature of this reagent lies in its propyl chain, which is longer than either the methyl or ethyl equivalent, producing ester derivatives with different polarity and different retention behaviour in chromatographic analysis. This difference is especially valuable when the peak of a methyl or ethyl derivative overlaps with components of the sample matrix, since the analyst can select propyl derivatisation instead to obtain better separation. The reaction conditions are mild and close to neutral, which preserves the integrity of other functional groups present in the molecule and reduces the risk of unwanted side reactions during derivatisation.

In Indonesian laboratories, reagents of this type are used in university synthesis groups, government research institutes, and analytical service laboratories that prepare samples for chromatographic determination. Because it works under gentle, near-neutral conditions and avoids the handling of strong acid catalysts, it fits well into routine sample-preparation workflows where a straightforward and reproducible derivatisation step is required before instrumental measurement, and where the choice of alkyl group must be adapted to the sample matrix at hand.

  • Direct esterification of carboxylic acids: converts the acid group into the corresponding propyl ester in a single step, without a strong acid catalyst or a large excess of alcohol under long reflux.
  • Derivatisation for chromatographic analysis: forms propyl ester derivatives with polarity and retention characteristics that differ from methyl and ethyl analogues, giving analysts an alternative when peaks overlap.
  • Resolution of matrix interference problems: when methyl or ethyl derivative peaks coincide with sample matrix components, switching to propyl derivatisation shifts retention and delivers better chromatographic separation.
  • Synthesis of propyl esters on substrates with sensitive functionality: the mild, near-neutral reaction conditions preserve other functional groups on the molecule that acidic esterification methods could damage.
  • Building block work in non-heterocyclic organic synthesis: serves alongside the dimethyl and diethyl acetal variants so researchers can select the ester alkyl group that matches their synthetic target.

Brand TCI
CAS number 6006-65-1
Molecular formula —
Purity —
Category Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes available in the packaging options offered by the manufacturer for this catalogue item
Physical form —
Storage —
  • Product code: D1301
  • Application grade: supplied as a reagent designated for esterification

Store the reagent in its original tightly closed container, protected from moisture, in a cool and well-ventilated area away from direct sunlight and sources of ignition. Acetal reagents of this type are moisture-sensitive, so containers should be resealed promptly after use and, where practical, handled under a dry inert atmosphere. Dispense and transfer the material inside a fume hood using clean, dry glassware and dry syringes or cannulas. Laboratory personnel should wear safety goggles, chemical-resistant gloves, and a laboratory coat, and should avoid inhaling vapours or allowing contact with skin and eyes. Keep the reagent separate from strong acids and strong oxidising agents, and consult the manufacturer's safety data sheet before use and before disposal of residues.

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