Methyl (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxylate TCI D2562

Name: TCI D2562 52373-72-5 Methyl (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxylate
Brand: TCI
SKU: TCI2510D256222823
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Berat 5g

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Description

TCI D2562 Methyl (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxylate, CAS 52373-72-5, is a chiral building block belonging to the family of materials used for asymmetric synthesis. The compound features a dioxolane ring that acts as an acetonide protecting group for two neighbouring hydroxyl groups, while at the same time carrying a methyl ester group that serves as a handle for further reaction. Because the (R) configuration is already fixed from the outset, this material is highly valuable for researchers who need to introduce a stereogenic centre into a target molecule without having to perform a racemic resolution or develop a dedicated asymmetric catalyst of their own.

The main reason this material is so widely chosen is the ease with which it can be handled. The acetonide group protects the diol stably under basic and neutral conditions, yet it can be reopened under aqueous acidic conditions whenever the free diol is required at a later stage of the synthesis. The methyl ester group is readily converted into an alcohol by reduction, into an amide by aminolysis, or into a carboxylic acid by hydrolysis, so that a single starting material can open onto many branching synthetic routes. This combination of preserved stereochemical purity and predictable reactivity is what makes it a dependable choice.

In Indonesian laboratories, this building block is typically used in university and institutional research groups working on asymmetric synthesis, in medicinal and natural-product chemistry projects where a defined stereocentre must be carried through a multi-step sequence, and in method-development work where a reliable chiral starting material shortens the route. Because the stereochemistry is supplied by the reagent itself, groups without access to specialised asymmetric catalysis facilities can still build enantiomerically defined targets.

Laboratory Applications

Asymmetric synthesis route design: the fixed (R) configuration allows a stereogenic centre to be introduced directly, removing the need for racemic resolution or in-house asymmetric catalyst development.
Protected diol chemistry: the acetonide ring holds two neighbouring hydroxyl groups safely through basic and neutral steps, then releases the free diol under aqueous acidic conditions.
Ester-to-alcohol transformations: the methyl ester is reduced cleanly to the corresponding alcohol, giving a chiral hydroxyl intermediate for onward coupling or functionalisation steps.
Amide bond construction: aminolysis of the methyl ester converts this building block into chiral amides, useful where a stereodefined amide fragment is needed in the target.
Carboxylic acid intermediate preparation: hydrolysis of the ester delivers the chiral carboxylic acid, letting one starting material branch into several different synthetic routes.

Specifications

Brand: TCI
CAS number: 52373-72-5
Category: Chemistry > Asymmetric Synthesis > Chiral Building Blocks
Chemical name: Methyl (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxylate
Pack sizes: available in TCI catalogue pack sizes; please confirm the size required when ordering
Storage: keep in the tightly closed original container, protected from moisture

Handling and Storage

Store the material in its tightly closed original container in a cool, dry, well-ventilated place, away from heat sources, direct sunlight and moisture, since the acetonide protecting group is sensitive to aqueous acidic conditions. Use containers compatible with organic esters and keep them clearly labelled. Handle in a fume hood using safety glasses, gloves and a laboratory coat, and avoid contact with skin, eyes and clothing as well as inhalation of vapours. Transfer with clean, dry glassware and reclose the container promptly after use. Keep the manufacturer's safety data sheet accessible to all users, and dispose of residues and contaminated materials as chemical waste in line with your institution's procedures.