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Description
TCI D2596 3,5-Difluorobenzoic Acid is a fluorinated building block built on a benzoic acid framework carrying two fluorine atoms at the meta positions relative to the carboxylic acid group. It serves as a frequently used starting material in organic synthesis because the carboxylic acid function acts as a universal connection point for the formation of amides, esters, acid chlorides, and hydrazides. The symmetry of the 3- and 5-positions gives the molecule a clean, predictable structure, allowing researchers to design downstream transformations without facing the isomer mixtures that complicate purification work in the laboratory.
The property that makes this compound a preferred choice is the strong influence of the two fluorine atoms on the electronic character of the molecule. Fluorine is highly electronegative and withdraws electron density from the aromatic ring, increasing the acidity of the carboxylic acid group and rendering the ring electron-poor. These conditions are advantageous in nucleophilic aromatic substitution reactions and also affect how the molecule interacts with biological targets. Fluorination further improves metabolic stability and tunes lipophilicity, two parameters of considerable importance in modern drug design programmes.
As a stable crystalline solid at room temperature, the material is convenient to weigh, transfer, and handle in routine Indonesian laboratory settings. It is typically used in university research groups, pharmaceutical and agrochemical development laboratories, and contract synthesis facilities where fluorinated intermediates are required. Its predictable behaviour and straightforward handling make it suitable both for exploratory small-scale reactions and for repeated preparative work where consistent starting material quality is expected.
Laboratory Applications
Amide bond formation — the carboxylic acid group serves as a universal coupling point, allowing direct conversion into amides for building libraries of fluorinated target molecules.
Ester and acid chloride synthesis — the reactive carboxylic acid function is readily converted into esters, acid chlorides, and hydrazides for further multi-step organic transformations.
Nucleophilic aromatic substitution studies — the electron-poor aromatic ring created by two meta fluorine atoms favours nucleophilic attack, making this an appropriate substrate for such reactions.
Medicinal chemistry intermediate preparation — fluorination improves metabolic stability and adjusts lipophilicity, two parameters researchers deliberately tune when designing drug candidate scaffolds.
Structure-activity relationship exploration — the symmetric 3,5-substitution pattern avoids troublesome isomer mixtures, giving predictable products and simpler purification during systematic analogue synthesis.
Specifications
Brand: TCI
Product code: D2596
CAS number: 455-40-3
Category: Chemistry > Building Blocks > Fluorinated Building Blocks
Physical form: crystalline solid, stable at room temperature
Pack sizes: please refer to the available packaging options listed for this catalogue item
Storage: keep in a tightly closed container in a cool, dry, well-ventilated area
Handling and Storage
Store the material in its original tightly closed container in a cool, dry, and well-ventilated area, protected from moisture and away from incompatible substances such as strong bases and strong oxidising agents. Glass bottles with chemically resistant closures are suitable for storage and for any repackaging of working quantities. Handle the solid inside a fume hood to avoid inhalation of dust, and wear appropriate personal protective equipment including safety glasses, gloves, and a laboratory coat. Avoid contact with skin and eyes, and close the container immediately after weighing to limit moisture uptake. Label all secondary containers clearly and follow the safety data sheet supplied by the manufacturer for detailed handling and disposal guidance.
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