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Description
TCI D2608 2,3-Dimethyl-4-nitrophenol is a substituted phenol that carries two methyl groups at the 2- and 3-positions together with a nitro group at the 4-position. The combination of a phenolic hydroxyl group, two methyl substituents, and a single nitro group makes it a useful non-heterocyclic starting material in organic synthesis, particularly when researchers require a phenol core with a dense and clearly defined substitution pattern. In the laboratory, this compound is used to build phenolic ether and ester derivatives, to prepare aminophenols by reduction, and as an intermediate in the development of dyes and active substances.
The characteristic that makes this compound a preferred choice is the interplay between the strongly electron-withdrawing nitro group and the electron-donating hydroxyl group. The nitro group increases the acidity of the phenol, so that deprotonation and O-alkylation reactions become easier to control, while at the same time serving as an amine precursor that can be reduced to the corresponding aminophenol. The two methyl groups surrounding the hydroxyl position introduce a distinctive steric hindrance that also influences the orientation of subsequent reactions, giving researchers a selectivity profile different from that of simple nitrophenols.
In Indonesian laboratories, this material is typically handled as a solid building block in university research groups, institutional research centres, and industrial R&D units working on organic synthesis. It is commonly used at bench scale for derivatisation studies, reduction routes towards aminophenols, and the preparation of intermediates for dye and active-ingredient development. Because it is supplied as a defined synthetic building block, it fits routine fume-hood work in synthesis laboratories where reproducible starting materials are required.
Laboratory Applications
- Synthesis of phenolic ethers: the increased phenol acidity conferred by the nitro group makes deprotonation and O-alkylation easier to control, giving cleaner and more predictable etherification.
- Preparation of phenolic esters: the free hydroxyl group provides a direct site for acylation, while the surrounding methyl groups give a distinctive steric environment during derivative formation.
- Reduction to aminophenols: the nitro group functions as an amine precursor, allowing researchers to convert the material into the corresponding aminophenol for further functionalisation.
- Dye development work: the compound serves as a synthetic intermediate in dye chemistry, where its defined substitution pattern supports building coloured target structures reproducibly.
- Active-substance intermediate synthesis: as a non-heterocyclic building block, it supplies a densely substituted phenol core for multi-step routes towards active compounds in research settings.
Specifications
- Brand: TCI
- Catalogue number: D2608
- CAS number: 19499-93-5
- Chemical name: 2,3-Dimethyl-4-nitrophenol
- Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
- Physical form: solid; pack sizes available on request
Handling and Storage
Store the material in a cool, dry, and well-ventilated place, kept tightly closed in its original manufacturer container or in an equivalent chemically compatible bottle with a secure closure. Protect the container from direct sunlight, moisture, heat sources, and ignition sources, and keep it separated from strong oxidising and reducing agents. Handle the solid inside a fume hood using suitable gloves, safety goggles, and a laboratory coat, and avoid generating or inhaling dust when weighing. Close the container immediately after use, label any prepared solutions clearly, and follow the manufacturer safety data sheet together with your institutional chemical waste procedures for disposal.
