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Description
TCI D2760 3,3-Diphenyl-1-propanol (CAS 20017-67-8) is an aliphatic primary alcohol that carries two phenyl rings on the third carbon atom of its chain. This structure combines a reactive hydroxyl group at the end of the chain with a bulky, rigid diphenylmethine centre, producing a non-heterocyclic building block with distinctive steric character. In the laboratory it serves as a starting material and as an intermediate for constructing molecules that require the 3,3-diphenylpropyl motif, a framework that appears across studies of bioactive compounds and in the development of organic ligands.
The property that makes this compound useful is the synthetic versatility of its primary hydroxyl group, which sits well away from the steric hindrance of the two phenyl rings and therefore remains readily accessible to reagents. This primary alcohol can be oxidised to the corresponding aldehyde or carboxylic acid, converted into leaving groups such as tosylates, mesylates, or halides for substitution reactions, and etherified or esterified without difficulty. The diphenyl portion, meanwhile, contributes lipophilicity and steric volume that influence the conformation of the final molecule. It is this combination of a flexible three-carbon chain with a doubly aromatic terminus that makes the compound a valuable connecting framework.
In Indonesian laboratories the material is typically used in organic synthesis groups at universities and research institutes, as well as in pharmaceutical and fine-chemical development work where a defined diphenylpropyl fragment is needed. It is commonly held as a shelf reagent for multi-step synthesis, drawn on for exploratory route development, functional-group interconversion studies, and the preparation of intermediates that are carried forward into larger target molecules. Its role is that of a dependable, well-characterised precursor rather than a finished product.
Laboratory Applications
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Multi-step organic synthesis — serves as a starting material for routes that require an intact 3,3-diphenylpropyl fragment, allowing chemists to introduce the whole motif in one operation rather than assembling it stepwise.
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Functional-group interconversion studies — the accessible primary hydroxyl can be oxidised, tosylated, mesylated, or halogenated, making the compound a convenient substrate for teaching and optimising standard transformations of primary alcohols.
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Preparation of ethers and esters — the unhindered terminal alcohol undergoes etherification and esterification readily, giving straightforward access to derivative libraries built on a common diphenylpropyl backbone.
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Bioactive compound research — the 3,3-diphenylpropyl framework recurs in studies of biologically active molecules, so this alcohol provides a direct, ready-made entry point into that scaffold for medicinal chemistry work.
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Organic ligand development — the bulky, rigid diphenylmethine centre supplies steric volume and lipophilicity that influence molecular conformation, properties that are useful when designing ligands with defined spatial requirements.
Specifications
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Brand: TCI (Tokyo Chemical Industry)
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CAS Number: 20017-67-8
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Catalogue Number: D2760
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Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
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Chemical Class: Aliphatic primary alcohol bearing two phenyl substituents at the C-3 position
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Pack Sizes: available in the standard research-scale packaging offered by the manufacturer; please confirm the pack size when ordering
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated area away from direct sunlight, heat sources, and incompatible materials such as strong oxidising agents. Keep the product in its original manufacturer container, or transfer it to a clean, chemically resistant, clearly labelled vessel with a secure closure. Handle in a fume hood using appropriate personal protective equipment, including safety goggles, gloves, and a laboratory coat, and avoid contact with skin and eyes as well as inhalation of dust or vapour. Use clean, dry spatulas to prevent contamination and reseal the container promptly after each use. Always consult the manufacturer's Safety Data Sheet before handling, and follow institutional procedures for waste disposal.
