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Description
TCI D3462 3,5-Difluorophenylacetic Acid is a fluorinated building block widely used in organic synthesis, particularly in medicinal chemistry and the development of test compounds. Its molecular structure consists of a benzene ring bearing two fluorine atoms at the meta positions, together with an acetic acid chain at position one, producing a carboxylic acid group connected through a benzylic methylene bridge. This combination delivers a compact yet high-value intermediate, because it allows researchers to introduce a difluoroaromatic substitution pattern into target molecules through well-established amide coupling or esterification reactions.
The property that makes this material a preferred choice is the strong influence of fluorine atoms on molecular behaviour. Fluorine is highly electronegative, so it lowers the electron density of the ring, increases the acidity of the carboxylic acid group, and modifies the solubility and metabolic stability of the resulting derivatives. Because fluorine is small, replacing a hydrogen atom with fluorine barely changes molecular geometry, yet it has a substantial impact on electronic properties and intermolecular interactions. In addition, the fluorine atoms provide a clear marker that assists analytical characterisation of the compound and its derivatives.
In Indonesian laboratories, this building block is typically used in university research groups, medicinal chemistry laboratories, and industrial research and development units that prepare fluorine-containing target molecules. It is generally handled at bench scale for exploratory synthesis, small-batch preparation of intermediates, and the assembly of compound libraries for screening. Because the reactions involved are standard carboxylic acid transformations, the material fits readily into existing synthetic workflows without requiring specialised equipment beyond ordinary organic synthesis facilities.
Laboratory Applications
- Medicinal chemistry synthesis: the difluoroaromatic pattern can be introduced into candidate molecules to adjust electronic properties, acidity, and metabolic stability without significantly altering the geometry of the parent structure.
- Amide coupling reactions: the free carboxylic acid group reacts through well-established coupling chemistry, making this reagent a straightforward way to append a difluorobenzyl fragment onto amine partners.
- Esterification and derivatisation: the benzylic acetic acid chain allows conversion into esters and related derivatives, giving researchers convenient access to a family of fluorinated analogues from one starting material.
- Test compound development: the material serves as a compact intermediate when preparing series of related structures for evaluation, since the fluorine substitution can be carried through subsequent synthetic steps.
- Analytical and structural studies: the fluorine atoms provide a clear spectroscopic marker, which supports characterisation and structural confirmation of the compound and the derivatives prepared from it.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- Product code: D3462
- CAS number: 105184-38-1
- Chemical name: 3,5-Difluorophenylacetic Acid
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Pack sizes: available in standard research-scale packaging as supplied by the manufacturer; please confirm the currently available pack size when ordering
- Storage: keep in the tightly closed original container, in a cool, dry, and well-ventilated place away from incompatible materials
Handling and Storage
Store this fluorinated building block in its tightly closed original container in a cool, dry, and well-ventilated area, protected from moisture, direct sunlight, and sources of heat or ignition. Keep it separated from strong bases and strong oxidising agents. Use chemically resistant containers with secure closures when transferring or preparing smaller working quantities, and label all secondary containers clearly. Handle the material inside a fume hood using standard personal protective equipment, including safety glasses, gloves, and a laboratory coat, and avoid generating or inhaling dust. Because it is a carboxylic acid, it may be irritating to skin, eyes, and the respiratory tract, so avoid direct contact and wash hands thoroughly after handling. Consult the manufacturer's safety data sheet before use, and follow local institutional procedures for waste collection and disposal.
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