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Description
TCI D3771 3,4-Difluorophenylacetic Acid, CAS number 658-93-5, is an arylacetic acid whose benzene ring carries two fluorine atoms at the 3 and 4 positions. The compound is classified as a fluorinated building block, meaning a starting material used to assemble larger target molecules. Its carboxylic acid group serves as the entry point for amidation, esterification, reduction, and acid chloride formation, which is why this compound appears frequently in medicinal chemistry and applied organic chemistry synthesis sequences carried out in research laboratories.
The feature that makes this material a preferred choice is the presence of the two fluorine atoms, which alter the electronic character of the aromatic ring. Fluorine substitution is commonly used to tune the acidity of nearby functional groups, increase metabolic stability, and adjust the lipophilicity of drug candidate molecules, so the difluorophenyl motif has become a popular option in molecular design. In addition, the fluorine atoms provide a highly useful marker for ¹⁹F NMR analysis, making reaction progress and product purity easier to follow. As a solid carboxylic acid, the material is also relatively easy to weigh, purify, and store.
Laboratories in Indonesia typically use this building block in university research groups, medicinal chemistry programmes, and applied organic synthesis work where fluorinated intermediates are required. Because it is supplied as a packaged reagent-grade chemical from TCI, it fits routine bench-scale synthesis planning, method development, and repeat preparations. The defined CAS identity also makes it straightforward to reference in procurement records, laboratory documentation, and published experimental sections.
Laboratory Applications
- Amide coupling and peptide-like bond formation, where the free carboxylic acid group reacts directly with amines to build difluorophenyl-substituted amide intermediates for further elaboration.
- Esterification chemistry, in which the acid is converted to esters that serve as protected or activated forms for subsequent transformations in multi-step organic synthesis routes.
- Acid chloride preparation, giving a highly reactive acylating agent that allows the difluorophenylacetyl fragment to be installed onto a wide range of nucleophilic partners.
- Medicinal chemistry scaffold construction, where the difluorophenyl motif is introduced to tune acidity, metabolic stability, and lipophilicity of candidate molecules under investigation.
- Reduction and functional group interconversion studies, since the carboxylic acid can be reduced or otherwise modified to access related alcohols and downstream fluorinated derivatives.
Specifications
- Brand: TCI
- CAS number: 658-93-5
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Product code: D3771
- Physical form: solid carboxylic acid
- Pack sizes: available in standard TCI catalogue pack sizes; please confirm the required size when ordering
- Storage: keep in a tightly closed original container in a cool, dry, well-ventilated chemical store
Handling and Storage
Store the material in its original tightly closed container in a cool, dry, well-ventilated area away from moisture, incompatible reagents, and strong bases or oxidising agents. Glass or chemically compatible plastic containers with secure closures are suitable for aliquots, and containers should remain clearly labelled with the compound name and CAS number. As with any solid organic acid, weigh and transfer the powder in a fume hood or well-ventilated workspace to avoid dust inhalation, and wear safety glasses, gloves, and a laboratory coat. Avoid skin and eye contact, clean up spills promptly with dry methods, and consult the manufacturer's safety data sheet before first use.
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